Browsing Institutt for klinisk og molekylær medisin by Journals "Atherosclerosis"
Now showing items 1-5 of 5
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Alpha-cyclodextrin inhibits cholesterol crystal-induced complement-mediated inflammation: A potential new compound for treatment of atherosclerosis.
(Peer reviewed; Journal article, 2019)Background and aims Cholesterol crystal (CC)-induced inflammation is a critical step in the development of atherosclerosis. CCs activate the complement system and induce an inflammatory response resulting in phagocytosis ... -
DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development
(Peer reviewed; Journal article, 2021)Background and aims Atherogenesis involves a complex interaction between immune cells and lipids, processes greatly influenced by the vascular smooth muscle cell (VSMC) phenotype. The DNA glycosylase NEIL3 has previously ... -
Increased levels of legumain in plasma and plaques from patients with carotid atherosclerosis
(Journal article; Peer reviewed, 2017)Background and aims The cysteine protease legumain has been shown to be up-regulated in unstable atherosclerotic plaques. This study aims to further elucidate legumain in atherosclerosis, by examining legumain in plasma ... -
Legumain is upregulated in acute cardiovascular events and associated with improved outcome – potentially related to anti-inflammatory effects on macrophages
(Peer reviewed; Journal article, 2019)Background and aims We have previously found increased levels of the cysteine protease legumain in plasma and plaques from patients with carotid atherosclerosis. This study further investigated legumain during acute ... -
The complement system and toll-like receptors as integrated players in the pathophysiology of atherosclerosis
(Peer reviewed; Journal article, 2015)Despite recent medical advances, atherosclerosis is a global burden accounting for numerous deaths and hospital admissions. Immune-mediated inflammation is a major component of the atherosclerotic process, but earlier ...