Browsing Institutt for klinisk og molekylær medisin by Author "Wendl, Thomas"
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Physiologically-based pharmacokinetic models for CYP1A2 drug-drug interaction prediction: A modeling network of fluvoxamine, theophylline, caffeine, rifampicin, and midazolam
Britz, Hannah; Hanke, Nina; Volz, Anke-Katrin; Spigset, Olav; Schwab, Matthias; Eissing, Thomas; Wendl, Thomas; Frechen, Sebastian; Lehr, Thorsten (Journal article; Peer reviewed, 2019)This study provides whole‐body physiologically‐based pharmacokinetic models of the strong index cytochrome P450 (CYP)1A2 inhibitor and moderate CYP3A4 inhibitor fluvoxamine and of the sensitive CYP1A2 substrate theophylline. ...