Browsing Institutt for teknisk kybernetikk by Subject "Artificial Pancreas"
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Blood Glucose Level Prediction Using Subcutaneous Sensors for in Vivo Study: Compensation for Measurement Method Slow Dynamics Using a Kalman Filter Approach
(Chapter, 2022)The continuous glucose monitoring (CGM) system is the most common system used by people with type 1 diabetes to monitor blood glucose levels. However, it measures glucose in interstitial fluid in subcutaneous tissue rather ... -
Connecting sensitivity, identifiability and interpretability of a glucose minimal model
(Chapter, 2024)Mathematical models have increased their applications in physiology, control and systems science, and biomedical engineering because they offer the opportunity to examine the structure and behavior of complex physiological ... -
Effect of sensor location on continuous intraperitoneal glucose sensing in an animal model
(Journal article; Peer reviewed, 2018)In diabetes research, the development of the artificial pancreas has been a major topic since continuous glucose monitoring became available in the early 2000’s. A prerequisite for an artificial pancreas is fast and reliable ... -
Estimation and Prediction of Glucose Appearance Rate for Use in a Fully Closed-Loop Dual-Hormone Intraperitoneal Artificial Pancreas
(Peer reviewed; Journal article, 2023)Objective: A fully automated artificial pancreas requires a meal estimator and predictions of blood glucose levels (BGL) to handle disturbances during meal times, all without relying on manual meal announcements and user ... -
Feasibility of Meal Onset Detection Using Electrocardiograms
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Fully Automated Bi-Hormonal Intraperitoneal Artificial Pancreas Using a Two-Layer PID Control Scheme
(Chapter, 2023)Treatment of type 1 diabetes mellitus is significantly improved by using commercially available hybrid closed-loop systems to deliver insulin. These systems, also called artificial pancreas (AP), use the subcutaneous (SC) ... -
Glucose-insulin metabolism model reduction and parameter selection using sensitivity analysis
(Journal article; Peer reviewed, 2019)Glucose-insulin metabolism models are useful tools for research on diabetes, in development of diabetes-related medical devices like artificial pancreas systems, insulin pumps and continuous glucose monitors, and may also ... -
Intraperitoneal insulin administration in pigs: Effect on circulating insulin and glucose levels
(Peer reviewed; Journal article, 2021)Introduction The effect of intraperitoneal insulin infusion has limited evidence in the literature. Therefore, the aim of the study was to investigate the pharmacokinetics and pharmacodynamics of different intraperitoneal ... -
Intraperitoneal, subcutaneous and intravenous glucagon delivery and subsequent glucose response in rats: A randomized controlled crossover trial
(Journal article; Peer reviewed, 2018)Objective Hypoglycemia is a frequent and potentially dangerous event among patients with diabetes mellitus type 1. Subcutaneous glucagon is an emergency treatment to counteract severe hypoglycemia. The effect of intraperitoneal ... -
Low-Order Nonlinear Animal Model of Glucose Dynamics for a Bihormonal Intraperitoneal Artificial Pancreas
(Peer reviewed; Journal article, 2021)Objective: The design of an Artificial Pancreas to regulate blood glucose levels requires reliable control methods. Model Predictive Control has emerged as a promising approach for glycemia control. However, model-based ... -
Modelling and simulation of occlusions in insulin pumps
(Chapter, 2021)Abstract — An open source simulation model of the mechanical properties of a fully functional insulin pump was made in Matlab Simscape. The model simulates realistic behavior of an insulin pump, parts of which are validated ... -
A Nonlinear State Observer for the Bi-Hormonal Intraperitoneal Artificial Pancreas
(Chapter, 2022)Currently, continuous glucose monitoring sensors are used in the artificial pancreas to monitor blood glucose levels. However, insulin and glucagon concentrations in different parts of the body cannot be measured in ... -
A Perspective on Harmonizing Diabetes Management Datasets
(Journal article; Peer reviewed, 2025)Diabetes management datasets are often compiled from various sensors and devices, including diabetes technology, activity trackers, and other health-related equipment, resulting in heterogeneous data formats. Despite the ...