Browsing NTNU Open by Author "Standal, Therese"
Now showing items 21-32 of 32
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The osteogenic properties of additive manufactured Titanium-6Aluminium-4Vanadium with focus on 3D geometry and surface topography
Ødegaard, Kristin Sirnes (Doctoral theses at NTNU;2023:77, Doctoral thesis, 2023) -
Osteogenic properties of human mesenchymal stem cells cultured on additively manufactured Ti-6Al-4V samples
Ouyang, Lingzi (Master thesis, 2020)Annually, hundreds of thousands of hip replacements are performed in the United States alone. This number is expected to increase with an increasing number of motor vehicle accidents and an increasingly active aging ... -
Paired miRNA- and messenger RNA-sequencing identifies novel miRNA-mRNA interactions in multiple myeloma
Aass, Kristin Roseth; Nedal, Tonje Marie Vikene; Tryggestad, Synne Stokke; Haukås, Einar; Slørdahl, Tobias Schmidt; Waage, Anders; Standal, Therese; Mjelle, Robin (Peer reviewed; Journal article, 2022)Multiple myeloma (MM) is an incurable cancer of terminally differentiated plasma cells that proliferate in the bone marrow. miRNAs are promising biomarkers for risk stratification in MM and several miRNAs are shown to have ... -
PDL1 expression on plasma and dendritic cells in myeloma bone marrow suggests benefit of targeted anti PD1-PDL1 therapy
Sponaas, Anne-Marit; Nejati Moharrami, Neda; Feyzi, Emadoldin; Standal, Therese; Rustad, Even Holth; Waage, Anders; Sundan, Anders (Peer reviewed; Journal article, 2015)In this study we set out to investigate whether anti PDL1 or PD–1 treatment targeting the immune system could be used against multiple myeloma. DCs are important in regulating T cell responses against tumors. We therefore ... -
The pro-tumorigenic cytokine IL-32 has a high turnover in multiple myeloma cells due to proteolysis regulated by oxygen-sensing cysteine dioxygenase and deubiquitinating enzymes
Kastnes, Martin Haugrud; Aass, Kristin Roseth; Bouma, Siri Anshushaug; Årseth, Charlotte; Zahoor, Muhammad; Yurchenko, Mariya; Standal, Therese (Peer reviewed; Journal article, 2023)IL-32 is a pro-inflammatory cytokine expressed by several types of cancer cells and immune cells. Currently, no treatment targeting IL-32 is available, and its intracellular and exosomal localization make IL-32 less ... -
Revealing the influence of electron beam melted Ti-6Al-4V scaffolds on osteogenesis of human bone marrow-derived mesenchymal stromal cells
Ødegaard, Kristin Sirnes; Ouyang, Lingzi; Ma, Qianli; Buene, Glenn; Wan, Di; Elverum, Christer Westum; Torgersen, Jan; Standal, Therese; Westhrin, Marita (Peer reviewed; Journal article, 2021)Porous Titanium-6Aluminum-4Vanadium scaffolds made by electron beam-based additive manufacturing (AM) have emerged as state-of-the-art implant devices. However, there is still limited knowledge on how they influence the ... -
The Role of IL-32 in Multiple Myeloma
Aass, Kristin Roseth (Doctoral theses at NTNU;2020:256, Doctoral thesis, 2020) -
Smac-mimetics reduce numbers and viability of human osteoclasts
Moen, Ingrid Nyhus; Westhrin, Marita; Håland, Erling; Haug, Markus; Nonstad, Unni; Klaharn, Merisa; Standal, Therese; Starheim, Kristian K. (Peer reviewed; Journal article, 2021)Elevated activity of bone-degrading osteoclasts (OC) contributes to pathological bone degradation in diseases such as multiple myeloma. Several proinflammatory cytokines, including TNF, contribute to osteoclastogenesis. ... -
The proportion of CD16+CD14dim monocytes increases with tumor cell load in bone marrow of patients with multiple myeloma
Sponaas, Anne-Marit; Moen, Siv Helen; Liabakk, Nina-Beate; Feyzi, Emadoldin; Holien, Toril; Kvam, Solveig; Grøseth, Lill Anny Gunnes; Størdal, Berit Fladvad; Buene, Glenn; Espevik, Terje; Waage, Anders; Standal, Therese; Sundan, Anders (Journal article; Peer reviewed, 2015)Multiple myeloma is an incurable cancer with expansion of malignant plasma cells in the bone marrow. Previous studies have shown that monocytes and macrophages in the bone marrow milieu are important for tumor growth ... -
The role of Toll-like receptors 4 and 9 in multiple myeloma cell viability and drug sensitivity
Ørning, Nadia Elise Helene (Master thesis, 2023)Myelomatose er en uhelbredelig sykdom karakterisert av tilstedeværelsen av maligne plasmaceller i benmargen, noe som fører til produksjon av monoklonale immunoglobuliner og tap av antistoffvariasjon. Toll-liknende reseptorer ... -
Toll-like receptor-mediated regulation of IL-32 in multiple myeloma cells
Tryggestad, Synne Stokke (Master thesis, 2020)Myelomatose, eller beinmargskreft, skyldes ukontrollert vekst av maligne plasmaceller i beinmargen. Pasienter med myelomatose er spesielt utsatt for infeksjoner, som også er en utbredt dødsårsak hos disse pasientene. ... -
Why do myeloma patients have bone disease? A historical perspective.
Børset, Magne; Sundan, Anders; Waage, Anders; Standal, Therese (Peer reviewed; Journal article, 2019)The question of how myeloma cells cause destruction of skeletal tissue has interested scientists for many years, and knowledge in this field has developed in parallel with the understanding of physiological bone remodeling. ...