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The proportion of CD16+CD14dim monocytes increases with tumor cell load in bone marrow of patients with multiple myeloma

Sponaas, Anne-Marit; Moen, Siv Helen; Liabakk, Nina-Beate; Feyzi, Emadoldin; Holien, Toril; Kvam, Solveig; Grøseth, Lill Anny Gunnes; Størdal, Berit Fladvad; Buene, Glenn; Espevik, Terje; Waage, Anders; Standal, Therese; Sundan, Anders
Journal article, Peer reviewed
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URI
http://hdl.handle.net/11250/298506
Date
2015
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  • Institutt for klinisk og molekylær medisin [2656]
  • Publikasjoner fra CRIStin - NTNU [26736]
Original version
Immunity,Inflammation and Disease 2015, 3(2):94-102   10.1002/iid3.53
Abstract
Multiple myeloma is an incurable cancer with expansion of malignant plasma cells

in the bone marrow. Previous studies have shown that monocytes and

macrophages in the bone marrow milieu are important for tumor growth and

may play a role in the drug response. We therefore characterized monocytes in

bone marrow aspirates by flow cytometry. We found that there was significant

correlation between the proportion of CX3CR1+, CD16+CD14dim non classical

monocytes, and percent plasma cells (PC) in the bone marrow of myeloma

patients. The bone marrow monocytes could be stimulated by TLR ligands to

produce cytokines which promote myeloma cell growth. The proportion of the

non-classical monocytes increased with the tumor load, particularly in patients

with tumor loads in the range of 10–30% bone marrow PC.
Description
-
Publisher
Wiley Open Access
Journal
Immunity, Inflammation and Disease

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