The proportion of CD16+CD14dim monocytes increases with tumor cell load in bone marrow of patients with multiple myeloma
Sponaas, Anne-Marit; Moen, Siv Helen; Liabakk, Nina-Beate; Feyzi, Emadoldin; Holien, Toril; Kvam, Solveig; Grøseth, Lill Anny Gunnes; Størdal, Berit Fladvad; Buene, Glenn; Espevik, Terje; Waage, Anders; Standal, Therese; Sundan, Anders
Journal article, Peer reviewed
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http://hdl.handle.net/11250/298506Utgivelsesdato
2015Metadata
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Sammendrag
Multiple myeloma is an incurable cancer with expansion of malignant plasma cells
in the bone marrow. Previous studies have shown that monocytes and
macrophages in the bone marrow milieu are important for tumor growth and
may play a role in the drug response. We therefore characterized monocytes in
bone marrow aspirates by flow cytometry. We found that there was significant
correlation between the proportion of CX3CR1+, CD16+CD14dim non classical
monocytes, and percent plasma cells (PC) in the bone marrow of myeloma
patients. The bone marrow monocytes could be stimulated by TLR ligands to
produce cytokines which promote myeloma cell growth. The proportion of the
non-classical monocytes increased with the tumor load, particularly in patients
with tumor loads in the range of 10–30% bone marrow PC.
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