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dc.contributor.authorAyyalasomayajula, Venkat Siva Radha Krishna
dc.contributor.authorErvik, Øyvind
dc.contributor.authorSorger, Hanne
dc.contributor.authorSkallerud, Bjørn Helge
dc.date.accessioned2024-01-30T12:50:18Z
dc.date.available2024-01-30T12:50:18Z
dc.date.created2024-01-26T10:05:45Z
dc.date.issued2024
dc.identifier.citationJournal of The Mechanical Behavior of Biomedical Materials. 2024, 151 .en_US
dc.identifier.issn1751-6161
dc.identifier.urihttps://hdl.handle.net/11250/3114505
dc.description.abstractMechanical characterization of hydrogels and ultra-soft tissues is a challenging task both from an experimental and material parameter estimation perspective because they are much softer than many biological materials, ceramics, or polymers. The elastic modulus of such materials is within the 1 - 100 kPa range, behaving as a hyperelastic solid with strain hardening capability at large strains. In the current study, indentation experiments have been performed on agarose hydrogels, bovine liver, and bovine lymph node specimens. This work reports on the reliable determination of the elastic modulus by indentation experiments carried out at the macro-scale (mm) using a spherical indenter. However, parameter identification of the hyperelastic material properties usually requires an inverse finite element analysis due to the lack of an analytical contact model of the indentation test. Hence a comprehensive study on the spherical indentation of hyperelastic soft materials is carried out through robust computational analysis. Neo-Hookean and first-order Ogden hyperelastic material models were found to be most suitable. A case study on known anisotropic hyperelastic material showed the inability of the inverse finite element method to uniquely identify the whole material parameter set.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleMacro-indentation testing of soft biological materials and assessment of hyper-elastic material models from inverse finite element analysisen_US
dc.title.alternativeMacro-indentation testing of soft biological materials and assessment of hyper-elastic material models from inverse finite element analysisen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber10en_US
dc.source.volume151en_US
dc.source.journalJournal of The Mechanical Behavior of Biomedical Materialsen_US
dc.identifier.doidoi.org/10.1016/j.jmbbm.2024.106389
dc.identifier.cristin2234995
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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