dc.contributor.author | Langseth, Øystein Olstad | |
dc.contributor.author | Myklebust, Tor Åge | |
dc.contributor.author | Johannessen, Tom Børge | |
dc.contributor.author | Hjertner, Øyvind | |
dc.contributor.author | Waage, Anders | |
dc.date.accessioned | 2023-05-25T07:50:01Z | |
dc.date.available | 2023-05-25T07:50:01Z | |
dc.date.created | 2022-05-03T13:32:22Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | European Journal of Haematology. 2022, 108 (6), 486-492. | en_US |
dc.identifier.issn | 0902-4441 | |
dc.identifier.uri | https://hdl.handle.net/11250/3068935 | |
dc.description.abstract | Objectives We conducted a population-based study to assess the risk for multiple myeloma (MM) and other cancers in first- and second-degree relatives of MM patients, and to investigate whether evidence of anticipation is present in familial MM. Methods We retrieved 24 845 first-degree relatives and 41 008 second-degree relatives of 7847 MM patients, and 86 984 first-degree relatives, and 138 660 second-degree relatives of 26 511 matched controls. A Cox model was used to assess the risk for MM and other cancers in relatives of MM patients. Anticipation was assessed by a Cox model, where all parents and offspring of MM patients were included in the risk set. Results In second-degree relatives of MM patients, no overall significant association with an MM diagnosis was observed (HR 1.99; 95%CI:0.86–4.57). In parents and offspring of MM patients, we found no significant difference in the ages at onset of MM (HR 1.28;95% CI:0.50–3.28). In affected parent-offspring pairs, we observed no statistically significant difference in overall survival between the generations (HR 0.74; 95%CI:0.20–2.69). Conclusions Overall, second-degree relatives of MM patients were not associated with an increased risk for MM. Our study supports that genetic anticipation is not present in familial MM. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.relation.uri | https://onlinelibrary.wiley.com/doi/10.1111/ejh.13757 | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Risk of multiple myeloma and other malignancies among first- and second-degree relatives of patients with multiple myeloma: A population-based study | en_US |
dc.title.alternative | Risk of multiple myeloma and other malignancies among first- and second-degree relatives of patients with multiple myeloma: A population-based study | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 486-492 | en_US |
dc.source.volume | 108 | en_US |
dc.source.journal | European Journal of Haematology | en_US |
dc.source.issue | 6 | en_US |
dc.identifier.doi | 10.1111/ejh.13757 | |
dc.identifier.cristin | 2020979 | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 1 | |