dc.contributor.author | Emblem, Åse | |
dc.contributor.author | Knutsen, Erik | |
dc.contributor.author | Jørgensen, Tor Erik | |
dc.contributor.author | Fure, Hilde | |
dc.contributor.author | Johansen, Steinar Daae | |
dc.contributor.author | Brekke, Ole Lars | |
dc.contributor.author | Mollnes, Tom Eirik | |
dc.contributor.author | Karlsen, Bård Ove | |
dc.date.accessioned | 2022-11-28T12:33:50Z | |
dc.date.available | 2022-11-28T12:33:50Z | |
dc.date.created | 2022-04-29T18:37:25Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Non-coding RNA. 2022, 8 (2), . | en_US |
dc.identifier.issn | 2311-553X | |
dc.identifier.uri | https://hdl.handle.net/11250/3034483 | |
dc.description.abstract | Many severe inflammation conditions are complement-dependent with the complement component C5a-C5aR1 axis as an important driver. At the RNA level, the blood transcriptome undergoes programmed expression of coding and long non-coding RNAs to combat invading microorganisms. Understanding the expression of long non-coding RNAs containing Alu elements in inflammation is important for reconstructing cell fate trajectories leading to severe disease. We have assembled a pipeline for computation mining of new Alu-containing long non-coding RNAs by intersecting immune genes with known Alu coordinates in the human genome. By applying the pipeline to patient bulk RNA-seq data with sepsis, we found immune genes containing 48 Alu insertion as robust candidates for further study. Interestingly, 1 of the 48 candidates was located within the complement system receptor gene C5aR1 and holds promise as a target for RNA therapeutics. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MDPI | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Blood Transcriptome Analysis of Septic Patients Reveals a Long Non-Coding Alu-RNA in the Complement C5a Receptor 1 Gene | en_US |
dc.title.alternative | Blood Transcriptome Analysis of Septic Patients Reveals a Long Non-Coding Alu-RNA in the Complement C5a Receptor 1 Gene | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.volume | 8 | en_US |
dc.source.journal | Non-coding RNA | en_US |
dc.source.issue | 2 | en_US |
dc.identifier.doi | 10.3390/ncrna8020024 | |
dc.identifier.cristin | 2020231 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |