dc.contributor.author | Hammer, Quirin | |
dc.contributor.author | Dunst, Josefine | |
dc.contributor.author | Christ, Wanda | |
dc.contributor.author | Picarazzi, Francesca | |
dc.contributor.author | Wendorff, Mareike | |
dc.contributor.author | Momayyezi, Pouria | |
dc.contributor.author | Huhn, Oisín | |
dc.contributor.author | Netskar, Herman Krogstad | |
dc.contributor.author | Maleki, Kimia T. | |
dc.contributor.author | García, Marina | |
dc.contributor.author | Sekine, Takuya | |
dc.contributor.author | Sohlberg, Ebba | |
dc.contributor.author | Azzimato, Valerio | |
dc.contributor.author | Aouadi, Myriam | |
dc.contributor.author | Holten, Aleksander Rygh | |
dc.contributor.author | Kildal, Anders Benjamin | |
dc.contributor.author | Lind, Andreas | |
dc.contributor.author | Dyrhol-Riise, Anne Ma | |
dc.contributor.author | Hoff, Dag Arne Lihaug | |
dc.contributor.author | Solligård, Erik | |
dc.contributor.author | Holter, Jan Cato | |
dc.contributor.author | Afset, Jan Egil | |
dc.contributor.author | Damås, Jan Kristian | |
dc.contributor.author | Hov, Johannes Espolin Roksund | |
dc.contributor.author | Bergan, Jonas | |
dc.contributor.author | Risnes, Kari | |
dc.contributor.author | Muller, Karl Erik | |
dc.contributor.author | Tonby, Kristian | |
dc.contributor.author | Heggelund, Lars | |
dc.contributor.author | Gustad, Lise Tuset | |
dc.contributor.author | Grimsrud, Marit Mæhle | |
dc.contributor.author | Vadla, May Sissel | |
dc.contributor.author | Lenning, Ole Bernt | |
dc.contributor.author | Myhre, Ronny | |
dc.contributor.author | Haider, Sammra | |
dc.contributor.author | Dudman, Susanne Gjeruldsen | |
dc.contributor.author | Karlsen, Tom Hemming | |
dc.contributor.author | Folseraas, Trine | |
dc.contributor.author | Skogen, Vegard | |
dc.contributor.author | Degenhardt, Frauke | |
dc.contributor.author | Franke, Andre | |
dc.contributor.author | Spallotta, Francesco | |
dc.contributor.author | Mori, Mattia | |
dc.contributor.author | Michaëlsson, Jakob | |
dc.contributor.author | Björkström, Niklas K. | |
dc.contributor.author | Rückert, Timo | |
dc.contributor.author | Romagnani, Chiara | |
dc.contributor.author | Horowitz, Amir | |
dc.contributor.author | Klingström, Jonas | |
dc.contributor.author | Ljunggren, Hans-Gustaf | |
dc.contributor.author | Malmberg, Karl-Johan | |
dc.date.accessioned | 2022-09-27T06:53:31Z | |
dc.date.available | 2022-09-27T06:53:31Z | |
dc.date.created | 2022-05-25T10:44:02Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Cell reports. 2022, 38 (10), . | en_US |
dc.identifier.issn | 2211-1247 | |
dc.identifier.uri | https://hdl.handle.net/11250/3021585 | |
dc.description.abstract | Natural killer (NK) cells are innate immune cells that contribute to host defense against virus infections. NK cells respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and are activated in patients with acute coronavirus disease 2019 (COVID-19). However, by which mechanisms NK cells detect SARS-CoV-2-infected cells remains largely unknown. Here, we show that the Non-structural protein 13 of SARS-CoV-2 encodes for a peptide that is presented by human leukocyte antigen E (HLA-E). In contrast with self-peptides, the viral peptide prevents binding of HLA-E to the inhibitory receptor NKG2A, thereby rendering target cells susceptible to NK cell attack. In line with these observations, NKG2A-expressing NK cells are particularly activated in patients with COVID-19 and proficiently limit SARS-CoV-2 replication in infected lung epithelial cells in vitro. Thus, these data suggest that a viral peptide presented by HLA-E abrogates inhibition of NKG2A+ NK cells, resulting in missing self-recognition. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Cell Press | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells | en_US |
dc.title.alternative | SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 14 | en_US |
dc.source.volume | 38 | en_US |
dc.source.journal | Cell reports | en_US |
dc.source.issue | 10 | en_US |
dc.identifier.doi | 10.1016/j.celrep.2022.110503 | |
dc.identifier.cristin | 2027260 | |
dc.relation.project | Norges forskningsråd: 312780 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |