Smoking and infertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study
dc.contributor.author | Hernáez, Álvaro | |
dc.contributor.author | Wootton, Robyn E | |
dc.contributor.author | Page, Christian Magnus | |
dc.contributor.author | Skåra, Karoline Hansen | |
dc.contributor.author | Fraser, Abigail | |
dc.contributor.author | Rogne, Tormod | |
dc.contributor.author | Magnus, Per Minor | |
dc.contributor.author | Njølstad, Pål Rasmus | |
dc.contributor.author | Andreassen, Ole | |
dc.contributor.author | Burgess, Stephen | |
dc.contributor.author | Lawlor, Deborah A. | |
dc.contributor.author | Magnus, Maria Christine | |
dc.date.accessioned | 2022-09-23T13:41:44Z | |
dc.date.available | 2022-09-23T13:41:44Z | |
dc.date.created | 2022-06-21T15:14:34Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Fertility and Sterility. 2022, 118 (1), 180-190. | en_US |
dc.identifier.issn | 0015-0282 | |
dc.identifier.uri | https://hdl.handle.net/11250/3020958 | |
dc.description.abstract | Objective: To investigate the association between smoking and infertility. Design: Prospective study. Setting: Nationwide cohort. Patients: 28,606 women and 27,096 men with questionnaire and genotype information from the Norwegian Mother, Father, and Child Cohort Study. Intervention: Self-reported information on smoking (having ever smoked [both sexes], age at initiation [women only], cessation [women only], and cigarettes/week in current smokers [both sexes]) was gathered. Genetically predetermined levels or likelihood of presenting these traits were estimated for Mendelian randomization. Main outcome: measure Infertility (time-to-pregnancy ≥12 months). Results: Having ever smoked was unrelated to infertility in women or men. Higher smoking intensity in women was associated with greater infertility odds (+1 standard deviation [SD, 48 cigarettes/week]: odds ratio [OR]crude, 1.19; 95% confidence interval [CI] 1.11–1.28; ORadjusted 1.12; 95% CI, 1.03–1.21), also after adjusting for the partner’s tobacco use. Later smoking initiation (+1 SD [3.2 years]: ORcrude, 0.94; 95% CI, 0.88–0.99; ORadjusted 0.89; 95% CI, 0.84–0.95) and smoking cessation (vs. not quitting: ORcrude, 0.83; 95% CI, 0.75–0.91; ORadjusted, 0.83; 95% CI, 0.75–0.93) were linked to decreased infertility in women. Nevertheless, Mendelian randomization results were not directionally consistent for smoking intensity and cessation and were estimated imprecisely in the 2-sample approach. In men, greater smoking intensity was not robustly associated with infertility in multivariable regression and Mendelian randomization. Conclusions: We did not find robust evidence of an effect of smoking on infertility. This may be due to a true lack of effect, weak genetic instruments, or other kinds of confounding. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Smoking and infertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study | en_US |
dc.title.alternative | Smoking and infertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 180-190 | en_US |
dc.source.volume | 118 | en_US |
dc.source.journal | Fertility and Sterility | en_US |
dc.source.issue | 1 | en_US |
dc.identifier.doi | 10.1016/j.fertnstert.2022.04.001 | |
dc.identifier.cristin | 2033947 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 |