dc.contributor.author | Sarjomaa, Marjut Anneli | |
dc.contributor.author | Diep, Lien My | |
dc.contributor.author | Zhang, Chi | |
dc.contributor.author | Tveten, Yngvar | |
dc.contributor.author | Reiso, Harald | |
dc.contributor.author | Thilesen, Carina | |
dc.contributor.author | Nordbø, Svein Arne | |
dc.contributor.author | Berg, Kristine Karlsrud | |
dc.contributor.author | Aaberge, Ingeborg Aase S. | |
dc.contributor.author | Pearce, Neil | |
dc.contributor.author | Kersten, Hege | |
dc.contributor.author | Vandenbroucke, Jan Paul | |
dc.contributor.author | Eikeland, Randi | |
dc.contributor.author | Fell, Anne Kristin M. | |
dc.date.accessioned | 2022-09-19T13:38:52Z | |
dc.date.available | 2022-09-19T13:38:52Z | |
dc.date.created | 2022-08-11T15:41:15Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | https://hdl.handle.net/11250/3018963 | |
dc.description.abstract | Objectives: To assess total antibody levels against Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS CoV-2) spike protein up to 12 months after Coronavirus Disease (COVID-19) infection in non-vaccinated individuals and the possible predictors of antibody persistence. Methods: This is the first part of a prospective multi-centre cohort study. Participants: The study included SARS-CoV-2 real-time polymerase chain reaction (RT-PCR) positive and negative participants in South-Eastern Norway from February to December 2020. Possible predictors of SARS-CoV-2 total antibody persistence was assessed. The SARS-CoV-2 total antibody levels against spike protein were measured three to five months after PCR in 391 PCR-positive and 703 PCR-negative participants; 212 PCR-positive participants were included in follow-up measurements at 10 to 12 months. The participants completed a questionnaire including information about symptoms, comorbidities, allergies, body mass index (BMI), and hospitalisation. Primary outcome: The SARS-CoV-2 total antibody levels against spike protein three to five and 10 to 12 months after PCR positive tests. Results: SARS-CoV-2 total antibodies against spike protein were present in 366 (94%) non-vaccinated PCR-positive participants after three to five months, compared with nine (1%) PCR-negative participants. After 10 to 12 months, antibodies were present in 204 (96%) non-vaccinated PCR-positive participants. Of the PCR-positive participants, 369 (94%) were not hospitalised. The mean age of the PCR-positive participants was 48 years (SD 15, range 20-85) and 50% of them were male. BMI ≥ 25 kg/m2 was positively associated with decreased antibody levels (OR 2.34, 95% CI 1.06 to 5.42). Participants with higher age and self-reported initial fever with chills or sweating were less likely to have decreased antibody levels (age: OR 0.97, 95% CI 0.94 to 0.99; fever: OR 0.33, 95% CI 0.13 to 0.75). Conclusion: Our results indicate that the level of SARS-CoV-2 total antibodies against spike protein persists for the vast majority of non-vaccinated PCR-positive persons at least 10 to 12 months after mild COVID-19. | en_US |
dc.description.abstract | SARS-CoV-2 antibody persistence after five and twelve months: A cohort study from South-Eastern Norway | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Public Library of Science | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | SARS-CoV-2 antibody persistence after five and twelve months: A cohort study from South-Eastern Norway | en_US |
dc.title.alternative | SARS-CoV-2 antibody persistence after five and twelve months: A cohort study from South-Eastern Norway | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.journal | PLOS ONE | en_US |
dc.identifier.doi | 10.1371/journal.pone.0264667 | |
dc.identifier.cristin | 2042519 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |