dc.contributor.author | Slagsvold, Katrine Hordnes | |
dc.contributor.author | Johnsen, Anne Berit | |
dc.contributor.author | Rognmo, Øivind | |
dc.contributor.author | Høydal, Morten | |
dc.contributor.author | Wisløff, Ulrik | |
dc.contributor.author | Wahba, Alexander | |
dc.date.accessioned | 2015-09-11T11:12:00Z | |
dc.date.accessioned | 2015-09-21T14:25:33Z | |
dc.date.available | 2015-09-11T11:12:00Z | |
dc.date.available | 2015-09-21T14:25:33Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Physiological Reports 2014, 2(e12124) | nb_NO |
dc.identifier.issn | 2051-817X | |
dc.identifier.uri | http://hdl.handle.net/11250/300967 | |
dc.description.abstract | Several of the cellular alterations involved in atrial fibrillation (AF) may be
linked to mitochondrial function and altered microRNA (miR) expression. A
majority of studies on human myocardium involve right atrial (RA) tissue
only. There are indications that AF may affect the two atria differentially. This
study aimed to compare interatrial differences in mitochondrial respiration
and miR expression in the RA versus left atrium (LA) within patients with
sinus rhythm (SR) and AF. Thirty-seven patients with AF (n = 21) or SR
(n = 16), undergoing coronary artery bypass surgery and/or heart valve surgery,
were included. Myocardial biopsies were obtained from RA and LA
appendages. Mitochondrial respiration was assessed in situ in permeabilized
myocardium. MiR array and real-time quantitative polymerase chain reaction
were performed to evaluate miR expression. Mitochondrial respiratory rates
were similar in RA versus LA. Expression of miR-100, -10b, -133a, -133b,
-146a, -155, -199a-5p, -208b, and -30b were different between the atria in both
SR and AF patients. In contrast, differential expression was observed between
RA versus LA for miR-93 in patients with SR only, and for miR-1, -125b,
-142-5p, -208a, and -92b within AF patients only. These results indicate that
mitochondrial respiratory capacity is similar in the RA and LA of patients with
SR and AF. Differences in miR expressional profiles are observed between the
RA versus LA in both SR and AF, and several interatrial differences in miR
expression diverge between SR and AF. These findings may contribute to the
understanding of how AF pathophysiology may affect the two atria differently. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | American Physiological Society | nb_NO |
dc.title | Comparison of left versus right atrial myocardium in patients with sinus rhythm or atrial fibrillation - an assessment of mitochondrial function and microRNA expression. | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | en_GB |
dc.date.updated | 2015-09-11T11:12:00Z | |
dc.source.volume | 2 | nb_NO |
dc.source.journal | Physiological Reports | nb_NO |
dc.identifier.doi | 10.14814/phy2.12124 | |
dc.identifier.cristin | 1207630 | |
dc.description.localcode | © 2014 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | nb_NO |