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dc.contributor.authorBrydøy, Marianne
dc.contributor.authorFosså, Sophie Dorothea
dc.contributor.authorKlepp, Olbjørn
dc.contributor.authorBremnes, Roy M.
dc.contributor.authorWist, Erik
dc.contributor.authorBjøro, Trine
dc.contributor.authorWentzel-Larsen, Tore
dc.contributor.authorDahl, Olav
dc.identifier.citationBritish Journal of Cancer. 2012, 107 (11), 1833-1839.en_US
dc.description.abstractBackground: The objective of this study was to assess markers of spermatogenesis in long-term survivors of testicular cancer (TC) according to treatment, and to explore correlations between the markers and associations with achieved paternity following TC treatment. Methods: In 1191 TC survivors diagnosed between 1980 and 1994, serum-follicle stimulating hormone (s-FSH; n=1191), s-inhibin B (n=441), and sperm counts (millions per ml; n=342) were analysed in a national follow-up study in 1998–2002. Paternity was assessed by a questionnaire. Results: At median 11 years follow-up, 44% had oligo- (<15 millions per ml; 29%) or azoospermia (15%). Sperm counts and s-inhibin B were significantly lower and s-FSH was higher after chemotherapy, but not after radiotherapy (RT), when compared with surgery only. All measures were significantly more abnormal following high doses of chemotherapy (cisplatin (Cis)>850 mg, absolute cumulative dose) compared with lower doses (Cis ⩽850 mg). Sperm counts were moderately correlated with s-FSH (−0.500), s-inhibin B (0.455), and s-inhibin B : FSH ratio (−0.524; all P<0.001). All markers differed significantly between those who had achieved post-treatment fatherhood and those with unsuccessful attempts. Conclusion: The RT had no long-term effects on the assessed markers of spermatogenesis, whereas chemotherapy had. At present, the routine evaluation of s-inhibin B adds little in the initial fertility evaluation of TC survivors.en_US
dc.publisherSpringer Natureen_US
dc.rightsNavngivelse-Ikkekommersiell-DelPåSammeVilkår 4.0 Internasjonal*
dc.titleSperm counts and endocrinological markers of spermatogenesis in long-term survivors of testicular canceren_US
dc.title.alternativeSperm counts and endocrinological markers of spermatogenesis in long-term survivors of testicular canceren_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.subject.nsiVDP::Onkologi: 762en_US
dc.subject.nsiVDP::Oncology: 762en_US
dc.source.journalBritish Journal of Canceren_US

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Navngivelse-Ikkekommersiell-DelPåSammeVilkår 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Navngivelse-Ikkekommersiell-DelPåSammeVilkår 4.0 Internasjonal