Vis enkel innførsel

Invasive lobular breast cancer: The prognostic impact of histopathological grade, E-cadherin and molecular subtypes

dc.contributor.authorEngstrøm, Monica J
dc.contributor.authorOpdahl, Signe
dc.contributor.authorVatten, Lars Johan
dc.contributor.authorHaugen, Olav Anton
dc.contributor.authorBofin, Anna M.
dc.date.accessioned2015-08-27T10:24:25Z
dc.date.accessioned2015-08-31T08:29:49Z
dc.date.available2015-08-27T10:24:25Z
dc.date.available2015-08-31T08:29:49Z
dc.date.issued2015
dc.identifier.citationHistopathology 2015, 66(3):409-419nb_NO
dc.identifier.issn1365-2559
dc.identifier.urihttp://hdl.handle.net/11250/298253
dc.description- Published articlenb_NO
dc.description.abstractAims The aim of this study was to compare breast cancer specific survival (BCSS) for invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) and, further, to evaluate critically the prognostic value of histopathological grading of ILC and examine E-cadherin as a prognostic marker in ILC. Methods and results The study comprised 116 lobular and 611 ductal breast carcinomas occurring between 1961 and 2008. All cases had been classified previously according to histopathological type and grade, stained for oestrogen receptor (ER), progesterone receptor (PR), antigen Ki67 (Ki67), epithelial growth factor receptor (EGFR), cytokeratin 5 (CK5) and human epidermal growth factor receptor 2 (HER2) and classified into molecular subtypes. For the present study, immunohistochemical staining for E-cadherin was performed. The Kaplan–Meier method and Cox proportional hazards models were used in the analyses. Grade 2 tumours comprised 85.3% of the lobular tumours and 51.9% of the ductal tumours. BCSS in ILC grade 2 was comparable to that of IDC grade 3. E-cadherin-negative ILC had a poorer prognosis compared to E-cadherin positive ILC and to IDC regardless of E-cadherin status. Conclusions The implication of histopathological grading may differ in ILC compared to IDC. E-cadherin may be useful in prognostication in ILC and thereby influence the determination of treatment strategies for this group of womennb_NO
dc.language.isoengnb_NO
dc.publisherJohn Wiley & Sons Ltd.nb_NO
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectbreast cancer; breast cancer-specific survival; E-cadherin; histopathological grade; invasive lobular carcinoma; prognosisnb_NO
dc.titleInvasive lobular breast cancer: The prognostic impact of histopathological grade, E-cadherin and molecular subtypesnb_NO
dc.typePeer revieweden_GB
dc.typeJournal articlenb_NO
dc.date.updated2015-08-27T10:24:25Z
dc.rights.holder© 2014 The Authors. Histopathology published by John Wiley & Sons Ltd.
dc.source.pagenumber409–419nb_NO
dc.source.volume66nb_NO
dc.source.journalHistopathologynb_NO
dc.source.issue3nb_NO
dc.identifier.doi10.1111/his.12572
dc.identifier.cristin1202461
dc.description.localcodeThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are madenb_NO


Tilhørende fil(er)

Thumbnail
Filnavn:
epdf.mht
Størrelse:
103.7Kb
Format:
Ukjent
Åpne

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made
Med mindre annet er angitt, så er denne innførselen lisensiert som This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made