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TOP2A gene copy number change in breast cancer

dc.contributor.authorEngstrøm, Monica J
dc.contributor.authorYtterhus, Borgny
dc.contributor.authorVatten, Lars Johan
dc.contributor.authorOpdahl, Signe
dc.contributor.authorBofin, Anna M.
dc.date.accessioned2015-08-27T10:21:44Z
dc.date.accessioned2015-08-31T07:54:36Z
dc.date.available2015-08-27T10:21:44Z
dc.date.available2015-08-31T07:54:36Z
dc.date.issued2014
dc.identifier.citationJournal of Clinical Pathology 2014, 67(5):420-425nb_NO
dc.identifier.issn0021-9746
dc.identifier.urihttp://hdl.handle.net/11250/298241
dc.description- Published article (CC BY-NC 3.0)nb_NO
dc.description.abstractAims The clinical significance of TOP2A as a prognostic marker has not been clarified. The aims of this study were to investigate the frequency of TOP2A copy number change; to correlate TOP2A with HER2 status, hormone receptor (HR) status and molecular subtype, and further to explore differences in breast cancer-specific survival according to TOP2A and HER2. Methods In this study, TOP2A, HER2 and chromosome 17 copy number were assessed in 670 cases of breast cancer using in situ hybridisation techniques. Gene to chromosome ratios ≥2 were classified as amplification. TOP2A deletion (gene to chromosome ratio ≤0.8) or monosomy (only one signal for both gene and chromosome in more than 75% of nuclei) were classified as gene loss. Results A strong association between TOP2A change and HR and HER2 status was found. During the first 5 years after diagnosis, the risk of death from breast cancer was significantly higher for cases with HER2 amplification irrespective of TOP2A status. Conclusions TOP2A copy number change was strongly associated with HR and HER2 status and as a prognostic marker TOP2A is probably of limited value.nb_NO
dc.language.isoengnb_NO
dc.publisherBMJ Publishing Groupnb_NO
dc.rightsThis is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/
dc.titleTOP2A gene copy number change in breast cancernb_NO
dc.typePeer revieweden_GB
dc.typeJournal articlenb_NO
dc.date.updated2015-08-27T10:21:44Z
dc.rights.holderPublished by the BMJ Publishing Group Limited (CC BY-NC 3.0)
dc.source.pagenumber420-425nb_NO
dc.source.volume67nb_NO
dc.source.journalJournal of Clinical Pathologynb_NO
dc.source.issue5nb_NO
dc.identifier.doi10.1136/jclinpath-2013-202052
dc.identifier.cristin1088302
dc.description.localcodeThis is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.nb_NO


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This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
Except where otherwise noted, this item's license is described as This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.