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Pituitary adenoma and headache

Gravdahl, Gøril Bruvik
Master thesis
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URI
http://hdl.handle.net/11250/296964
Date
2015
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  • Institutt for samfunnsmedisin og sykepleie [2408]
Abstract
Background: Although headache and pituitary adenoma are two prevalent conditions that

may coexist, it has also been postulated that pituitary adenomas may cause secondary

headaches that resemble primary headaches. Headache alone is so far a controversial

indication for treatment of pituitary adenoma.

Purpose: To gain knowledge about the relationship between pituitary tumours and headache,

and possible symptomatic effects of treatment.

Materials and method: Patients diagnosed with or treated for pituitary adenomas in a 10-year period in a single institution were invited to participate in the study. The 208 (86%)

included patients underwent structured telephone interviews concerning current and prior

headache complaints while type of tumour, endocrine variables, treatment variables, MRI

variables and headache history were recorded from medical records. Headache prevalence

among patients was compared to identical measures of headache prevalence from a regional

population based study in volunteers.

Results: The current cross sectional age and sex-adjusted 1-year prevalence of headache

suffering (21%) is significantly lower than the general population (37%) p<0.001. Assessed

retrospectively, prevalence of headaches was significantly higher (48%) p<0.001 before being

diagnosed with pituitary adenomas than in the general population. With the exception of

family history of headache (p=0.020), no associations between headache and measured

clinical or radiological variables were identified.

Conclusion: Although patients retrospectively reported relief of headache complaints after

treatment current prevalence of headaches among patients harbouring both treated and

untreated pituitary adenomas is low compared to the general population. Furthermore, the

lack of variables associated with headache suggests that headache alone as a sole indication

for treatment of pituitary tumours is still debatable
Publisher
NTNU

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