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Risk factors of cycle acceleration in acutely admitted patients with bipolar disorder

Finseth, Per Ivar; Morken, Gunnar; Malt, Ulrik Fredrik; Andreassen, Ole Andreas; Vaaler, Arne Einar
Journal article, Peer reviewed
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URI
http://hdl.handle.net/11250/284062
Date
2014
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  • Institutt for nevromedisin og bevegelsesvitenskap [1713]
  • Publikasjoner fra CRIStin - NTNU [21000]
Original version
Acta Psychiatrica Scandinavica 2014, 130(5):388-396   10.1111/acps.12308
Abstract
Obje ctive: To identify risk factors associated with cycle acceleration

(CA), that is, progressive decrease in duration of syndrome-free

intervals between affective episodes, in acutely admitted patients with

bipolar disorder (BD).

Method : All patients ( n = 210) with BD I (67%) and BD II (33%)

(DSM-IV) acutely admitted to a hospital serving a catchment area were

compared in retrospect with regard to a positive or negative history of

CA. Putative risk factors of CA with a P-value <0.05 in uni-variate tests

were secondly entered into a logistic regression model.

Res ults: The logistic regression model was statistically significant

(P < 0.0001) and explained between 45.3% and 60.5% of the variance

of CA status. 83.7% of the cases were correctly classified with a

sensitivity of 87.2% and a specificity of 80.4%. Unique significant risk

factors of CA were increasing severity of affective episodes (odds ratio

(OR) = 28.8), BD II (OR = 3.3), hypomanic/manic episode induced by

an antidepressant and/or alcohol (OR = 3.3), and female gender

(OR = 3.1).

Conc lusion: The clinical factors associated with CA may help targeting

patients with BD with a course aggravation, and are in line with

previously reported neuropathological processes of illness progression.

Key words: bipolar disorder; in-patient; cycle

acceleration; risk factors
Publisher
Wiley
Journal
Acta Psychiatrica Scandinavica

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