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dc.contributor.authorTrimmel, Simone
dc.contributor.authorVike-Jonas, Kristine
dc.contributor.authorGonzalez, Susana Villa
dc.contributor.authorCiesielski, Tomasz Maciej
dc.contributor.authorLindstrøm, Ulf
dc.contributor.authorJenssen, Bjørn Munro
dc.contributor.authorAsimakopoulos, Alexandros
dc.date.accessioned2021-10-12T13:08:18Z
dc.date.available2021-10-12T13:08:18Z
dc.date.created2021-08-17T14:27:43Z
dc.date.issued2021
dc.identifier.citationToxics. 2021, 9 (8), .en_US
dc.identifier.issn2305-6304
dc.identifier.urihttps://hdl.handle.net/11250/2789365
dc.description.abstractA rapid hybrid solid phase extraction (HybridSPE®) protocol tailored to ultra-performance liquid chromatography–electrospray ionization tandem mass spectrometry (UPLC®–ESI–MS/MS) analysis was developed for the determination of 15 per- and polyfluoroalkyl substances (PFAS) in liver tissue from harbour porpoises (Phocoena phocoena). The HybridSPE® technique has been applied in trace concentration bioanalysis, but it was mainly used for liquid biological media until now. In this study, the protocol was applied on tissue matrix, and it demonstrated acceptable absolute recoveries (%) ranging from 44.4 to 89.4%. The chromatographic separation was carried out using a gradient elution program with a total run time of 4 min. The inter-day method precision ranged from 2.15 to 15.4%, and the method limits of detection (LODs) ranged from 0.003 to 0.30 ng/g wet weight (w.w.). A total of 20 liver samples were analyzed to demonstrate the applicability of the developed method in liver tissue from a wildlife species.en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleRapid Determination of Per- and Polyfluoroalkyl Substances (PFAS) in Harbour Porpoise Liver Tissue by HybridSPE®–UPLC®–MS/MSen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber11en_US
dc.source.volume9en_US
dc.source.journalToxicsen_US
dc.source.issue8en_US
dc.identifier.doi10.3390/toxics9080183
dc.identifier.cristin1926662
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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