Association of smoking and cancer with the risk of venous thromboembolism: the Scandinavian Thrombosis and Cancer cohort
dc.contributor.author | Paulsen, Benedikte | |
dc.contributor.author | Gran, Olga Vikhammer | |
dc.contributor.author | Severinsen, Marianne T. | |
dc.contributor.author | Hammerstrøm, Jens | |
dc.contributor.author | Kristensen, Søren Risom | |
dc.contributor.author | Cannegieter, Suzanne C. | |
dc.contributor.author | Skille, Hanne | |
dc.contributor.author | Tjønneland, Anne | |
dc.contributor.author | Rosendaal, Frits | |
dc.contributor.author | Overvad, Kim | |
dc.contributor.author | Næss, Inger Anne | |
dc.contributor.author | Hansen, John-Bjarne | |
dc.contributor.author | Brækkan, Sigrid K. | |
dc.date.accessioned | 2021-10-08T11:12:51Z | |
dc.date.available | 2021-10-08T11:12:51Z | |
dc.date.created | 2021-10-04T09:51:43Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Scientific Reports. 2021, 11, . | en_US |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://hdl.handle.net/11250/2788703 | |
dc.description.abstract | Smoking is a well-established risk factor for cancer, and cancer patients have a high risk of venous thromboembolism (VTE). Conflicting results have been reported on the association between smoking and risk of VTE, and the effect of smoking on VTE-risk in subjects with cancer is scarcely studied. We aimed to investigate the association between smoking and VTE in subjects with and without cancer in a large population-based cohort. The Scandinavian Thrombosis and Cancer (STAC) cohort included 144,952 participants followed from 1993–1997 to 2008–2012. Information on smoking habits was derived from self-administered questionnaires. Active cancer was defined as the first two years following the date of cancer diagnosis. Former smokers (n = 35,890) and those with missing information on smoking status (n = 3680) at baseline were excluded. During a mean follow up of 11 years, 10,181 participants were diagnosed with cancer, and 1611 developed incident VTE, of which 214 were cancer-related. Smoking was associated with a 50% increased risk of VTE (HR 1.49, 95% CI 1.12–1.98) in cancer patients, whereas no association was found in cancer-free subjects (HR 1.07, 95% CI 0.96–1.20). In cancer patients, the risk of VTE among smokers remained unchanged after adjustment for cancer site and metastasis. Stratified analyses showed that smoking was a risk factor for VTE among those with smoking-related and advanced cancers. In conclusion, smoking was associated with increased VTE risk in subjects with active cancer, but not in those without cancer. Our findings imply a biological interaction between cancer and smoking on the risk of VTE. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer Nature | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Association of smoking and cancer with the risk of venous thromboembolism: the Scandinavian Thrombosis and Cancer cohort | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.volume | 11 | en_US |
dc.source.journal | Scientific Reports | en_US |
dc.identifier.doi | 10.1038/s41598-021-98062-0 | |
dc.identifier.cristin | 1942877 | |
dc.source.articlenumber | 18752 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 |
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