Show simple item record

dc.contributor.authorArnstad, Ellen Dalen
dc.contributor.authorGlerup, Mia
dc.contributor.authorRypdal, Veronika Gjertsen
dc.contributor.authorPeltoniemi, Suvi
dc.contributor.authorFasth, Anders
dc.contributor.authorNielsen, Susan
dc.contributor.authorZak, Marek
dc.contributor.authorAalto, Kristiina
dc.contributor.authorBerntson, Lillemor
dc.contributor.authorNordal, Ellen Berit
dc.contributor.authorHerlin, Troels
dc.contributor.authorRomundstad, Pål Richard
dc.contributor.authorRygg, Marite
dc.identifier.citationPediatric Rheumatology. 2021, 19 .en_US
dc.description.abstractBackground: To study fatigue in young adults with juvenile idiopathic arthritis (JIA) 18 years after disease onset, and to compare with controls. Methods: Consecutive children with onset of JIA between 1997 and 2000, from geographically defined areas of Norway, Sweden, Denmark and Finland were followed for 18 years in a close to population-based prospective cohort study. Clinical features, demographic and patient-reported data were collected. Inclusion criteria in the present study were a baseline visit 6 months after disease onset, followed by an 18-year follow-up with available self-reported fatigue score (Fatigue Severity Scale (FSS), 1–7). Severe fatigue was defined as FSS ≥4. For comparison, Norwegian age and sex matched controls were used. Results: Among 377 young adults with JIA, 26% reported severe fatigue, compared to 12% among controls. We found higher burden of fatigue among participants with sleep problems, pain, poor health, reduced participation in school/work, physical disability, active disease, or use of disease-modifying anti-rheumatic drugs (DMARDs)/ biologics/systemic steroids. In contrast, participants without these challenges, had fatigue scores similar to controls. Active disease assessed at all three time points (baseline, 8-year and 18-year follow-up) was associated with higher mean fatigue score and higher percentage of severe fatigue compared to disease courses characterized by periods of inactive disease. Predictors of fatigue at the 18-year follow-up were female sex and diagnostic delay of ≥6 months at baseline, and also pain, self-reported poor health, active disease, and previous/ongoing use of DMARDs/ biologics at 8 years.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleFatigue in young adults with juvenile idiopathic arthritis 18 years after disease onset: data from the prospective Nordic JIA cohorten_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.source.journalPediatric Rheumatologyen_US

Files in this item


This item appears in the following Collection(s)

Show simple item record

Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal