dc.contributor.author | Konstantinidis, Ioannis | |
dc.contributor.author | Anastasiadi, Dafni | |
dc.contributor.author | Sætrom, Pål | |
dc.contributor.author | Nedoluzhko, Artem | |
dc.contributor.author | Mjelle, Robin | |
dc.contributor.author | Podgorniak, Tomasz | |
dc.contributor.author | Piferrer, Francesc | |
dc.contributor.author | Fernandes, Jorge Manuel de Oliveira | |
dc.date.accessioned | 2021-07-06T08:04:13Z | |
dc.date.available | 2021-07-06T08:04:13Z | |
dc.date.created | 2021-07-03T10:07:51Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Genomics. 2021, 113 (5), 2953-2964. | en_US |
dc.identifier.issn | 0888-7543 | |
dc.identifier.uri | https://hdl.handle.net/11250/2763491 | |
dc.description.abstract | In vertebrates, the somatotropic axis comprising the pituitary gland, liver and muscle plays a major role in myogenesis. Its output in terms of muscle growth is highly affected by nutritional and environmental cues, and thus likely epigenetically regulated. Hydroxymethylation is emerging as a DNA modification that modulates gene expression but a holistic characterization of the hydroxymethylome of the somatotropic axis has not been investigated to date. Using reduced representation 5-hydroxymethylcytosine profiling we demonstrate tissue-specific localization of 5-hydroxymethylcytosines at single nucleotide resolution. Their abundance within gene bodies and promoters of several growth-related genes supports their pertinent role in gene regulation. We propose that cytosine hydroxymethylation may contribute to the phenotypic plasticity of growth through epigenetic regulation of the somatotropic axis. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Ltd. | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Epigenetic mapping of the somatotropic axis in Nile tilapia reveals differential DNA hydroxymethylation marks associated with growth | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 2953-2964 | en_US |
dc.source.volume | 113 | en_US |
dc.source.journal | Genomics | en_US |
dc.source.issue | 5 | en_US |
dc.identifier.doi | https://doi.org/10.1016/j.ygeno.2021.06.037 | |
dc.identifier.cristin | 1920178 | |
dc.relation.project | EC/H2020/683210 | en_US |
dc.relation.project | EC/H2020/812986 | en_US |
dc.relation.project | Norges forskningsråd: 250548 | en_US |
dc.description.localcode | This is an open access article distributed under the terms of the Creative Commons CC-BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |