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dc.contributor.authorAnderson, Emma L.
dc.contributor.authorRichmond, Rebecca C.
dc.contributor.authorJones, Samuel E.
dc.contributor.authorHemani, Gibran
dc.contributor.authorWade, Kaitlin H
dc.contributor.authorDashti, Hassan S.
dc.contributor.authorLane, Jaqueline
dc.contributor.authorWang, Heming
dc.contributor.authorSaxena, Richa
dc.contributor.authorBrumpton, Ben Michael
dc.contributor.authorKorologou-Linden, Roxanna
dc.contributor.authorNielsen, Jonas Bille
dc.contributor.authorÅsvold, Bjørn Olav
dc.contributor.authorAbecasis, Goncalo
dc.contributor.authorCoulthard, Elizabeth
dc.contributor.authorKyle, Simon D.
dc.contributor.authorBeaumont, Robin N.
dc.contributor.authorTyrell, Jessica
dc.contributor.authorFrayling, Timothy M
dc.contributor.authorMunafo, Marcus R
dc.contributor.authorWood, Andrew R
dc.contributor.authorBen-Shlomo, Yoav
dc.contributor.authorHowe, Laura D
dc.contributor.authorLawlor, Deborah A.
dc.contributor.authorWeedon, Michael N
dc.contributor.authorSmith, George Davey
dc.date.accessioned2021-05-18T09:18:40Z
dc.date.available2021-05-18T09:18:40Z
dc.date.created2021-02-09T23:10:17Z
dc.date.issued2020
dc.identifier.citationInternational Journal of Epidemiology. 2020, dyaa183, .en_US
dc.identifier.issn0300-5771
dc.identifier.urihttps://hdl.handle.net/11250/2755390
dc.description.abstractBackground It is established that Alzheimer’s disease (AD) patients experience sleep disruption. However, it remains unknown whether disruption in the quantity, quality or timing of sleep is a risk factor for the onset of AD. Methods We used the largest published genome-wide association studies of self-reported and accelerometer-measured sleep traits (chronotype, duration, fragmentation, insomnia, daytime napping and daytime sleepiness), and AD. Mendelian randomization (MR) was used to estimate the causal effect of self-reported and accelerometer-measured sleep parameters on AD risk. Results Overall, there was little evidence to support a causal effect of sleep traits on AD risk. There was some suggestive evidence that self-reported daytime napping was associated with lower AD risk [odds ratio (OR): 0.70, 95% confidence interval (CI): 0.50–0.99). Some other sleep traits (accelerometer-measured ‘eveningness’ and sleep duration, and self-reported daytime sleepiness) had ORs of a similar magnitude to daytime napping, but were less precisely estimated. Conclusions Overall, we found very limited evidence to support a causal effect of sleep traits on AD risk. Our findings provide tentative evidence that daytime napping may reduce AD risk. Given that this is the first MR study of multiple self-report and objective sleep traits on AD risk, findings should be replicated using independent samples when such data become available.en_US
dc.language.isoengen_US
dc.publisherOxford University Press on behalf of the International Epidemiological Associationen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleIs disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysisen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.volumedyaa183en_US
dc.source.journalInternational Journal of Epidemiologyen_US
dc.identifier.doi10.1093/ije/dyaa183
dc.identifier.cristin1888306
dc.description.localcode© The Author(s) 2020. Published by Oxford University Press on behalf of the International Epidemiological Association. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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