Vis enkel innførsel

dc.contributor.authorFuglerud, Silje Skeide
dc.contributor.authorEllingsen, Reinold
dc.contributor.authorAksnes, Astrid
dc.contributor.authorHjelme, Dag Roar
dc.description.abstractNear infrared spectroscopy (NIR) is a promising technique for continuous blood glucose monitoring for diabetic patients. Four interferents, at physiological concentrations, were introduced to study how the glucose predictions varied with a standard multivariate calibration model. Lactate and ethanol were found to interfere strongly with the glucose predictions unless theywere included in the calibration models. Lactate was mistaken for glucose and gave erroneously high glucose predictions, with a dose response of 0.46 mM/mM. The presence of ethanol resulted in too low glucose predictions, with a dose response of -0.43 mM/mM. Acetaminophen (APAP), a known interferent in the glucose monitoring devices used for diabetes management today, was not found to be an interferent in NIR spectroscopy, nor was caffeine. Thus, interferents that may appear in high concentrations, such as ethanol and lactate, must be included in the calibration or model building of future NIR-based glucose measurement devices for diabetes monitoring.en_US
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.titleInvestigation of the effect of clinically relevant interferents on glucose monitoring using near‐infrared spectroscopyen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalJournal of Biophotonicsen_US
dc.relation.projectRegionalt helseforetak: 46055510en_US
dc.relation.projectNorges forskningsråd: 248872en_US
dc.description.localcode© 2021 The Authors. Journal of Biophotonics published by Wiley‐VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.en_US

Tilhørende fil(er)


Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Navngivelse-Ikkekommersiell 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Navngivelse-Ikkekommersiell 4.0 Internasjonal