Blar i Publikasjoner fra CRIStin - NTNU på tittel

Viser treff 21157-21176 av 37221

    • Metabolic characterization of triple negative breast cancer 

      Cao, Maria Dung; Lamichhane, Santosh; Lundgren, Steinar; Bofin, Anna M.; Fjøsne, Hans Erikssønn; Giskeødegård, Guro F.; Bathen, Tone Frost (Journal article; Peer reviewed, 2014)
      Background The aims of this study were to characterize the metabolite profiles of triple negative breast cancer (TNBC) and to investigate the metabolite profiles associated with human epidermal growth factor receptor-2/neu ...

    • Metabolic clusters of breast cancer in relation to gene- and protein expression subtypes 

      Haukaas, Tonje Husby; Euceda, Leslie R.; Giskeødegård, Guro F.; Lamichhane, Santosh; Krohn, Marit; Jernstrøm, Sandra; Aure, Miriam Ragle; Lingjærde, Ole Christian; Schlichting, Ellen; Garred, Øystein; Due, Eldri Undlien; Mills, Gordon B.; Sahlberg, Kristine Kleivi; Børresen-Dale, Anne-Lise; Bathen, Tone Frost; (OSBREAC), Oslo Breast Cancer Consortium (Journal article; Peer reviewed, 2016)
      Background: The heterogeneous biology of breast cancer leads to high diversity in prognosis and response to treatment, even for patients with similar clinical diagnosis, histology, and stage of disease. Identifying ...

    • Metabolic cold acclimation of 'Polka' and 'Honeoye' strawberries under natural field conditions 

      Rohloff, Jens; Eidem, Petter; Davik, Jahn Eldar; Alsheikh-Yousef, Muath (Journal article; Peer reviewed, 2014)
      The winter hardiness of strawberry varieties used in perennial production systems varies greatly. Still, little information is available on how plant metabolism adapts to cold and freezing temperatures under natural ...

    • Metabolic consequences of perioperative oral carbohydrates in breast cancer patients - an explorative study 

      Lende, Tone Hoel; Austdal, Marie; Bathen, Tone Frost; Varhaugvik, Anne Elin; Skaland, Ivar; Gudlaugsson, Einar; Egeland, Nina Gran; Lunde, Siri; Akslen, Lars A.; Jonsdottir, Kristin; Janssen, Emiel; Søiland, Håvard; Baak, Jan P.A. (Journal article; Peer reviewed, 2019)
      Background The metabolic consequences of preoperative carbohydrate load in breast cancer patients are not known. The present explorative study investigated the systemic and tumor metabolic changes after preoperative ...

    • Metabolic effects of signal transduction inhibition in cancer assessed by magnetic resonance spectroscopy 

      Moestue, Siver Andreas; Engebråten, Olav; Gribbestad, Ingrid S (Journal article; Peer reviewed, 2011)
      Despite huge efforts in development of drugs targeting oncogenic signalling, the number of such drugs entering clinical practice to date remains limited. Rational use of biomarkers for drug candidate selection and early ...

    • Metabolic engineering of Corynebacterium glutamicum for de novo production of 3-hydroxycadaverine 

      Prell, Carina; Vonderbank, Sophie-Ann; Meyer, Florian; Perez-Garcia, Fernando; Wendisch, Volker F. (Peer reviewed; Journal article, 2022)
      Functionalization of amino acids and their derivatives opens up the possibility to produce novel compounds with additional functional groups, which can expand their application spectra. Hydroxylation of polyamide building ...

    • Metabolic Engineering of thermophilic Bacillus methanolicus for riboflavin overproduction from methanol 

      Klein, Vivien Jessica; Brito, Luciana Fernandes; Perez-Garcia, Fernando; Brautaset, Trygve; Irla, Marta Katarzyna (Peer reviewed; Journal article, 2023)
      The growing need of next generation feedstocks for biotechnology spurs an intensification of research on the utilization of methanol as carbon and energy source for biotechnological processes. In this paper, we introduced ...

    • Metabolic load comparison between the quarters of a game in elite male basketball players using sport metabolomics 

      Khoramipour, Kayvan; Gaeini, Abbbas Ali; Shirzad, Elham; Gilany, Kambiz; Chashniam, Saeed; Sandbakk, Øyvind (Peer reviewed; Journal article, 2020)
      Purpose: A basketball match is characterized by intermittent high-intensity activities, thereby relying extensively on both aerobic and anaerobic metabolic pathways. Here, we aimed to compare the metabolic fluctuations ...

    • Metabolic memory underlying minimal residual disease in breast cancer 

      Shechter, Ksenija Radic; Kafkia, Eleni; Zirngibl, Katharina; Gawrzak, Sylwia; Alladin, Ashna; Machado, Daniel; Lüchtenborg, Christian; Sévin, Daniel C.; Brügger, Britta; Patil, Kiran R.; Jechlinger, Martin (Peer reviewed; Journal article, 2021)
      Tumor relapse from treatment-resistant cells (minimal residual disease, MRD) underlies most breast cancer-related deaths. Yet, the molecular characteristics defining their malignancy have largely remained elusive. Here, ...

    • Metabolic portraits of breast cancer by HR MAS MR spectroscopy of intact tissue samples 

      Haukaas, Tonje Husby; Euceda, Leslie R.; Giskeødegård, Guro F.; Bathen, Tone Frost (Journal article; Peer reviewed, 2017)
      Despite progress in early detection and therapeutic strategies, breast cancer remains the second leading cause of cancer-related death among women globally. Due to the heterogeneity and complexity of tumor biology, breast ...

    • Metabolic predispositions and increased risk of colorectal adenocarcinoma by anatomical location: a large population-based cohort study in Norway 

      Lu, Yunxia; Ness-Jensen, Eivind; Hveem, Kristian; Martling, Anna (Journal article; Peer reviewed, 2015)
      Whether different definitions of metabolic syndrome (MetS) are differently associated with colorectal adenocarcinoma (CA) by anatomical location is unclear. A population-based cohort study, the Cohort of Norway (CONOR) ...

    • Metabolic profiles of brain metastases 

      Sjøbakk, Torill Eidhammer; Vettukattil, Riyas M; Gulati, Michel; Gulati, Sasha; Lundgren, Steinar; Gribbestad, Ingrid S; Torp, Sverre Helge; Bathen, Tone Frost (Journal article; Peer reviewed, 2013)
      Metastasis to the brain is a feared complication of systemic cancer, associated with significant morbidity and poor prognosis. A better understanding of the tumor metabolism might help us meet the challenges in controlling ...

    • Metabolic profiles of placenta in preeclampsia using HR-MAS MRS metabolomics 

      Austdal, Marie; Thomsen, Liv Cecilie Vestrheim; Tangerås, Line Haugstad; Skei, Bente; Mathew, Seema; Bjørge, Line; Austgulen, Rigmor; Bathen, Tone Frost; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2015)
      Introduction Preeclampsia is a heterogeneous gestational disease characterized by maternal hypertension and proteinuria, affecting 2–7% of pregnancies. The disorder is initiated by insufficient placental development, ...

    • Metabolic profiling of colorectal cancer organoids: A comparison between high-resolution magic angle spinning magnetic resonance spectroscopy and solution nuclear magnetic resonance spectroscopy of polar extracts 

      van der Kemp, Wybe J. M.; Grinde, Maria Tunset; Malvik, Jon Olav; van Laarhoven, Hanneke W. M.; Prompers, Jeanine J.; Klomp, Dennis W. J.; Burgering, Boudewijn; Bathen, Tone Frost; Moestue, Siver Andreas (Peer reviewed; Journal article, 2022)
      Patient-derived cancer cells cultured in vitro are a cornerstone of cancer metabolism research. More recently, the introduction of organoids has provided the research community with a more versatile model system. Physiological ...

    • Metabolic Profiling of CSF from People Suffering from Sporadic and LRRK2 Parkinson's Disease: A Pilot Study 

      Yilmaz, Ali; Ugur, Zafer; Ustun, Ilyas; Akyol, Sumeyya; Bahado-Singh, Ray O.; Maddens, Michael; Aasly, Jan; Graham, Stewart F. (Journal article; Peer reviewed, 2020)
      CSF from unique groups of Parkinson’s disease (PD) patients was biochemically profiled to identify previously unreported metabolic pathways linked to PD pathogenesis, and novel biochemical biomarkers of the disease were ...

    • Metabolic Profiling of Glucose-Fed Metabolically Active Resting Zymomonas mobilis Strains 

      Fuchino, Katsuya; Kalnenieks, Uldis; Rutkis, Reinis; Grube, Mara; Bruheim, Per (Peer reviewed; Journal article, 2020)
      Zymomonas mobilis is the most efficient bacterial ethanol producer and its physiology is potentially applicable to industrial-scale bioethanol production. However, compared to other industrially important microorganisms, ...

    • Metabolic re-wiring of isogenic breast epithelial cell lines following epithelial to mesenchymal transition 

      Haldorsson, Skarphedinn; Rohatgi, Neha; Magnusdottir, Manuela; Choudhary, Kumari; Gudjónsson, Thorarinn; Knutsen, Erik; Barkovskaya, Anna; Hilmarsdòttir, Bylgja; Perander, Maria; Mælandsmo, Gunhild; Gudmundsson, Steinn; Rolfsson, Ottar (Journal article; Peer reviewed, 2017)
      Epithelial to mesenchymal transition (EMT) has implications in tumor progression and metastasis. Metabolic alterations have been described in cancer development but studies focused on the metabolic re-wiring that takes ...

    • Metabolic reprogramming supports the invasive phenotype in malignant melanoma 

      Bettum, Ingrid Johanne; Gorad, Saurabh Sayajirao; Barkovskaya, Anna; Pettersen, Solveig; Moestue, Siver Andreas; Vasiliauskaite, Kotryna; Tenstad, Ellen; Øyjord, Tove Ragnhild; Risa, Øystein; Nygaard, Vigdis; Mælandsmo, Gunhild; Prasmickaite, Lina (Journal article; Peer reviewed, 2015)
      Invasiveness is a hallmark of aggressive cancer like malignant melanoma, and factors involved in acquisition or maintenance of an invasive phenotype are attractive targets for therapy. We investigated melanoma phenotype ...

    • Metabolic response to everolimus in patient-derived triple negative breast cancer xenografts 

      Euceda, Leslie R.; Hill, Deborah Katherine; Stokke, Endre; Hatem, Rana; Botty, Rania; Bieche, Ivan; Marangoni, Elisabetta; Bathen, Tone Frost; Moestue, Siver Andreas (Journal article; Peer reviewed, 2017)
      Patients with triple-negative breast cancer (TNBC) are unresponsive to endocrine and anti-HER2 pharmacotherapy, limiting their therapeutic options to chemotherapy. TNBC is frequently associated with abnormalities in the ...

    • Metabolic syndrome and esophageal and gastric cancer 

      Lin, Yulan; Ness-Jensen, Eivind; Hveem, Kristian; Lagergren, Jesper; Yunxia, Lu (Journal article; Peer reviewed, 2015)
      Background The role of the metabolic syndrome in the etiology of esophageal and gastric cancer is unclear. Methods This was a large nationwide cohort study based on data from 11 prospective population-based cohorts ...