Blar i Publikasjoner fra CRIStin - NTNU på tittel

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    • Genetic consequences of conservation action: Restoring the arctic fox (Vulpes lagopus) population in Scandinavia 

      Hemphill, Elisa June Keeling; Flagstad, Øystein; Jensen, Henrik; Norén, Karin; Wallén, Johan Fredrik; Landa, Arild Magne; Angerbjörn, Anders; Eide, Nina Elisabeth (Peer reviewed; Journal article, 2020)
      The Arctic fox (Vulpes lagopus) population in Fennoscandia experienced a drastic bottleneck in the late 19th century as a result of high hunting pressure. In the 1990s, despite nearly 70 years of protection, the population ...

    • Genetic control of variability in subcortical and intracranial volumes 

      Còrdova Palomera, Aldo; van der Meer, Dennis; Kaufmann, Tobias; Bettella, Francesco; Wang, Yunpeng; Alnæs, Dag; Doan, Nhat Trung; Agartz, Ingrid; Bertolino, Alessandro; Buitelaar, Jan; Coynel, David; Djurovic, Srdjan; Dørum, Erlend Solberg; Espeseth, Thomas; Fazio, Leonardo; Franke, Barbara; Frei, Oleksandr; Håberg, Asta; Le Hellard, Stephanie; Jönsson, Erik Gunnar; Kolskår, Knut-Kristian; Lund, Martina Jonette; Moberget, Torgeir; Nordvik, Jan; Nyberg, Lars; Papassotiropoulos, Andreas; Pergola, Giulio; de Quervain, Dominique; Rampino, Antonio; Richard, Geneviève; Rokicki, Jaroslav; Sanders, Anne-Marthe; Schwarz, Emanuel; Smeland, Olav Bjerkehagen; Steen, Vidar Martin; Starrfelt, Jostein; Sønderby, Ida Elken; Ulrichsen, Kristine Moe; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Peer reviewed; Journal article, 2020)
      Sensitivity to external demands is essential for adaptation to dynamic environments, but comes at the cost of increased risk of adverse outcomes when facing poor environmental conditions. Here, we apply a novel methodology ...

    • Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults 

      Hofer, Edith; Roshchupkin, Gennady V.; Adams, Hieab H H; Knol, Maria J.; Lin, Honghuang; Li, Shuo; Zare, Habil; Ahmad, Shahzad; Armstrong, Nicola J.; Satizabal, Claudia L.; Panizzon, Matthew S.; Andreassen, Ole Andreas; Dale, Anders M.; Logue, Mark; Grasby, Katrina L.; Van Duijn, Cornelia M.; Grabe, Hans J.; Longstreth, William T.; Fornage, Myriam; Paus, Tomas; Debette, Stephanie; Ikram, M. Arfan; Schmidt, Helena; Schmidt, Reinhold; Seshadri, Sudha; Agartz, Ingrid; Alhusaini, Saud; Almeida, Marcio A.A.; Alnæs, Dag; Amlien, Inge Kasbohm; Doan, Nhat Trung; Gurholt, Tiril Pedersen; Kaufmann, Tobias; Richard, Geneviève; Sønderby, Ida Elken; van der Meer, Dennis; Wang, Yunpeng; Westlye, Lars Tjelta; Brandt, Christine Lycke; Djurovic, Srdjan; Kolskår, Knut-Kristian; Melle, Ingrid; Nordvik, Jan Egil; Steen, Vidar Martin; Espeseth, Thomas; Håberg, Asta; Wright, Margaret J.; Zhou, Juan; Stein, Jason L.; Thompson, Paul M.; Medland, Sarah E. (Peer reviewed; Journal article, 2020)
      Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these ...

    • Genetic deletion of MMP12 ameliorates cardiometabolic disease by improving insulin sensitivity, systemic inflammation, and atherosclerotic features in mice 

      Amor, Melina; Bianco, Valentina; Buerger, Martin; Lechleitner, Margarete; Vujić, Nemanja; Dobrijević, Anja; Akhmetshina, Alena; Pirchheim, Anita; Schwarz, Birgit; Pessentheiner, Ariane R.; Baumgartner, Franziska; Rampitsch, Katharina; Schauer, Silvia; Klobučar, Iva; Degoricija, Vesna; Pregartner, Gudrun; Kummer, Daniel; Svecla, Monika; Sommer, Gerhard; Kolb, Dagmar; Holzapfel, Gerhard; Hoefler, Gerald; Frank, Saša; Norata, Giuseppe Danilo; Kratky, Dagmar (Journal article; Peer reviewed, 2023)
      Background Matrix metalloproteinase 12 (MMP12) is a macrophage-secreted protein that is massively upregulated as a pro-inflammatory factor in metabolic and vascular tissues of mice and humans suffering from cardiometabolic ...

    • Genetic diversity and drug resistance pattern of Mycobacterium tuberculosis strains isolated from pulmonary tuberculosis patients in the Benishangul Gumuz region and its surroundings, Northwest Ethiopia 

      Lobie, Tekle Airgecho; Woldeamanuel, Yimtubezinash; Asrat, Daniel; Beyene, Demissew Balcha; Bjørås, Magnar; Aseffa, Abraham (Peer reviewed; Journal article, 2020)
      Introduction Tuberculosis (TB) remains a major global public health problem and is the leading cause of death from a single bacterium, Mycobacterium tuberculosis (MTB) complex. The emergence and spread of drug-resistant ...

    • Genetic diversity of rotavirus strains circulating in Norway before and after the introduction of rotavirus vaccination in children 

      Gibory, Moustafa; Bruun, Tone; Flem, Elmira; Dembinski, Jennifer Lynn; Haltbakk, Ildri; Størdal, Ketil; Nordbø, Svein Arne; Jakobsen, Kirsti; Haarr, Elisebet; Leegaard, Truls Michael; Dudman, Susanne Gjeruldsen (Peer reviewed; Journal article, 2021)
      Globally, rotavirus (RV) is the leading cause of acute gastroenteritis (AGE) in young children under 5 years of age. Implementation of RV vaccination is expected to result in fewer cases of RV in the target population, but ...

    • Genetic Effects on Longitudinal Changes from Healthy to Adverse Weight and Metabolic Status—The HUNT Study 

      Kvaløy, Kirsti; Holmen, Jostein; Hveem, Kristian; Holmen, Turid Lingaas (Journal article; Peer reviewed, 2015)
      Introduction: The complexity of obesity and onset and susceptibility of cardio-metabolic disorders are still poorly understood and is addressed here through studies of genetic influence on weight gain and increased ...

    • Genetic epidemiology of amyotrophic lateral sclerosis in Norway - a 2-year population based study 

      Olsen, Cathrine Goberg; Busk, Øyvind Løvold; Aanjesen, Tori Navestad; Alstadhaug, Karl Bjørnar; Bjørnå, Ingrid Kristine; Braathen, Geir Julius; Breivik, Kristin Lif; Demic, Natasha; Flemmen, Heidi Øyen; Hallerstig, Erika; HogenEsch, Ineke; Holla, Øystein Lunde; Jøntvedt, Anne Berit; Kampman, Margitta T.; Kleveland, Grethe; Kvernmo, Helene Ballo; Ljøstad, Unn; Maniaol, Angelina; Morsund, Åse Hagen; Nakken, Ola; Novy, Camilla; Rekand, Tiina; Schlüter, Katrin Ruth; Schuler, Stephan; Tveten, Kristian; Tysnes, Ole-Bjørn; Holmøy, Trygve; Høyer, Helle (Peer reviewed; Journal article, 2022)
      Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons. In Europe, disease-causing genetic variants have been identified in 40-70% of familial ALS patients and approximately ...

    • Genetic evolution, plasticity, and bet-hedging as adaptive responses to temporally autocorrelated fluctuating selection: A quantitative genetic model 

      Tufto, Jarle (Journal article; Peer reviewed, 2015)
      Adaptive responses to autocorrelated environmental fluctuations through evolution in mean reaction norm elevation and slope and an independent component of the phenotypic variance are analyzed using a quantitative genetic ...

    • The genetic history of Scandinavia from the Roman Iron Age to the present 

      Rodriguez-Varela, Ricardo; Moore, Kristjan H.S.; Ebenesersdottir, Sunna; Kilinc, Gulsah; Kjellström, Anna; Papmehl-Dufay, Ludvig; Alfsdotter, Clara; Berglund, Birgitta; Alrawi, Loey; Kashuba, Natlija; Sobrado, Veronica; Lagerholm, Vendela Kempe; Gilbert, Edmund; Cavalleri, Gianpiero L.; Hovig, Eivind; Kockum, Ingrid; Olsson, Tomas; Alfredsson, Lars; Hansen, Thomas F.; Werge, Thomas; Munters, Arielle R.; Bernhardsson, Carolina; Skar, Birgitte; Christophersen, Axel; Turner-Walker, Gordon; Gopalakrishnan, Shyam; Daskalaki, Evangelia; Omrak, Ayca; Perez-Ramallo, Patxi; Skoglund, Pontus; Girdland-Flink, Linus; Gunnarsson, Fredrik; Hedenstierna-Jonson, Charlotte; Gilbert, Marcus Thomas Pius; Lidén, Kerstin; Jakobsson, Mattias; Einarsson, Lars Petter; Victor, Helena; Krzewinska, Maja; Zachrisson, Torun; Storå, Jan; Stefánsson, Kári; Helgason, Agnar; Götherström, Anders (Peer reviewed; Journal article, 2023)
      We investigate a 2,000-year genetic transect through Scandinavia spanning the Iron Age to the present, based on 48 new and 249 published ancient genomes and genotypes from 16,638 modern individuals. We find regional variation ...

    • The genetic impact of an Ebola outbreak on a wild gorilla population 

      Fontsere, Claudia; Frandsen, Peter; Hernandez-Rodriguez, Jessica; Niemann, Jonas; Scharff-Olsen, Camilla Hjorth; Vallet, Dominique; Le Gouar, Pascaline; Ménard, Nelly; Navarro, Arcadi; Siegismund, Hans Redlef; Hvilsom, Christina; Gilbert, Marcus Thomas Pius; Kuhlwilm, Martin; Hughes, David; Marques-Bonet, Tomas (Peer reviewed; Journal article, 2021)
      Background Numerous Ebola virus outbreaks have occurred in Equatorial Africa over the past decades. Besides human fatalities, gorillas and chimpanzees have also succumbed to the fatal virus. The 2004 outbreak at the ...

    • Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes 

      Gusarova, Viktoria; O'Dushlaine, Colm; Teslovich, Tanya M.; Benotti, Peter N.; Mirshahi, Tooraj; Gottesman, Omri; van Hout, Cristopher V.; Murray, Michael F.; Mahajan, Anubha; Nielsen, Jonas B.; Fritsche, Lars; Wulff, Anders Berg; Gudbjartsson, Daníel Fannar; Sjögren, Marketa; Emdin, Connor A.; Scott, Robert A.; Lee, Wen-Jane; Small, Aeron; Kwee, Lydia C.; Dwivedi, Om Prakash; Prasad, Rashmi B.; Bruse, Shannon; Lopez, Alexander E.; Penn, John; Marcketta, Anthony; Leader, Joseph B.; Still, Christopher D.; Kirchner, H. Lester; Mirshahi, Uyenlinh L.; Wardeh, Amr H.; Hartle, Cassandra M.; Habegger, Lukas; Fetterolf, Samantha N.; Tusie-Luna, Teresa; Morris, Andrew P.; Holm, Hilma; Steinthorsdóttir, Valgerdur; Sulem, Patrick; Thorsteinsdóttir, Unnur; Rotter, Jerome I.; Chuang, Lee-Ming; Damrauer, Scott; Birtwell, David; Brummett, Chad M.; Khera, Amit V.; Natarajan, Pradeep; Orho-Melander, Marju; Flannick, Jason; Lotta, Luca A.; Willer, Cristen J.; Holmen, Oddgeir Lingaas; Ritchie, Marylyn D.; Ledbetter, David H.; Murphy, Andrew J.; Borecki, Ingrid B.; Reid, Jeffrey G.; Overton, John D.; Hansson, Ola; Groop, Leif; Shah, Svati H.; Kraus, William E.; Rader, Daniel J.; Chen, Yii-Der Ida; Hveem, Kristian; Wareham, Nicholas J.; Kathiresan, Sekar; Melander, Olle; Stefansson, Kari; Nordestgaard, Børge G.; Tybjærg-Hansen, Anne; Abecasis, Goncalo; Altshuler, David; Florez, Jose C.; Boehnke, Michael; McCarthy, Mark I.; Yancopoulos, George D.; Carey, David J.; Shuldiner, Alan R.; Baras, Aris; Dewey, Frederick E.; Gromada, Jesper (Journal article; Peer reviewed, 2018)
      Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient partitioning. We hypothesize that loss of ANGPTL4 function might improve ...

    • Genetic insight into sick sinus syndrome 

      Thorolfsdottir, Rosa B.; Sveinbjornsson, Gardar; Aegisdottir, Hildur M.; Benonisdottir, Stefania; Stefánsdóttir, Lilja; Ivarsdottir, Erna V.; Halldorsson, Gisli H.; Sigurdsson, Jon K.; Torp-Pedersen, Christian; Weeke, Peter E.; Brunak, Søren; Westergaard, David; Pedersen, Ole B.; Sorensen, Erik; Nielsen, Kaspar R.; Burgdorf, Kristoffer S.; Banasik, Karina; Brumpton, Ben Michael; Zhou, Wei; Oddsson, Asmundur; Tragante, Vinicius; Hjorleifsson, Kristjan E.; Davidsson, Olafur B.; Rajamani, Sridharan; Jonsson, Stefan; Torfason, Bjarni; Valgardsson, Atli S.; Thorgeirsson, Gudmundur; Frigge, Michael L.; Thorleifsson, Gudmar; Norddahl, Gudmundur L.; Helgadottir, Anna; Gretarsdotti, Solveig; Sulem, Patrick; Jonsdottir, Ingileif; Willer, Cristen J.; Hveem, Kristian; Bundgaard, Henning; Ullum, Henrik; Arnar, David O.; Thorsteinsdottir, Unnur; Gudbjartsson, Daniel F.; Holm, Hilma; Stefansson, Kari (Peer reviewed; Journal article, 2021)

    • Genetic interaction between DNA repair factors PAXX, XLF, XRCC4 and DNA-PKcs in human cells 

      Xing, Mengtan; Oksenych, Valentyn (Journal article; Peer reviewed, 2019)
      DNA double‐strand breaks (DSBs) are highly cytotoxic lesions, and unrepaired or misrepaired DSBs can lead to various human diseases, including immunodeficiency, neurological abnormalities, growth retardation, and cancer. ...

    • Genetic interaction between the non‐homologous end joining factors during B and T lymphocyte development: in vivo mouse models 

      Castaneda Zegarra, Sergio Miguel; Fernandez Berrocal, Marion Silvana; Tkachev, Max; Yao, Rouan; Esnardo Upfold, Nikki Lyn; Oksenych, Valentyn (Peer reviewed; Journal article, 2020)
      Non-homologous end joining (NHEJ) is the main DNA repair mechanism for the repair of double-strand breaks (DSBs) throughout the course of the cell cycle. DSBs are generated in developing B and T lymphocytes during V(D)J ...

    • Genetic Load and Adaptive Potential of a Recovered Avian Species that Narrowly Avoided Extinction 

      Femerling, Georgette; van Oosterhout, Cock; Feng, Shaohong; Bristol, Rachel M.; Zhang, Guojie; Groombridge, Jim; Gilbert, Marcus Thomas Pius; Morales, Hernán E (Journal article; Peer reviewed, 2023)
      High genetic diversity is a good predictor of long-term population viability, yet some species persevere despite having low genetic diversity. Here we study the genomic erosion of the Seychelles paradise flycatcher ...

    • Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies 

      Gorski, Mathias; Rasheed, Humaira; Teumer, Alexander; Thomas, Laurent; Graham, Sarah E.; Sveinbjornsson, Gardar; Winkler, Thomas W.; Günther, Felix; Stark, Klaus J.; Chai, Jin-Fang; Tayo, Bamidele O.; Wuttke, Matthias; Li, Yong; Tin, Adrienne; Ahluwalia, Tarunveer S.; Ärnlöv, Johan; Åsvold, Bjørn Olav; Bakker, Stephan J.L.; Banas, Bernhard; Bansal, Nisha; Biggs, Mary L.; Biino, Ginevra; Böhnke, Michael; Boerwinkle, Eric; Bottinger, Erwin P.; Brenner, Hermann; Brumpton, Ben Michael; Carroll, Robert J.; Chaker, Layal; Chalmers, John; Chee, Miao-Li; Chee, Miao-Ling; Cheng, Ching-Yu; Chu, Audrey Y.; Ciullo, Marina; Cocca, Massimiliano; Cook, James P.; Coresh, Josef; Cusi, Daniele; de Borst, Martin H.; Degenhardt, Frauke; Eckardt, Kai-Uwe; Endlich, Karlhans; Evans, Michele K.; Feitosa, Mary F.; Franke, Andre; Freitag-Wolf, Sandra; Fuchsberger, Christian; Gampawar, Piyush; Gansevoort, Ron T.; Ghanbari, Mohsen; Ghasemi, Sahar; Giedraitis, Vilmantas; Gieger, Christian; Gudbjartsson, Daniel F.; Hallan, Stein; Hamet, Pavel; Hishida, Asahi; Ho, Kevin; Hofer, Edith; Holleczek, Bernd; Holm, Hilma; Hoppmann, Anselm; Horn, Katrin; Hutri-Kähönen, Nina; Hveem, Kristian; Hwang, Shih-Jen; Ikram, M. Arfan; Josyula, Navya Shilpa; Jung, Bettina; Kähönen, Mika; Karabegović, Irma; Khor, Chiea-Chuen; Koenig, Wolfgang; Kramer, Holly; Krämer, Bernhard K.; Kühnel, Brigitte; Kuusisto, Johanna; Laakso, Markku; Lange, Leslie A.; Lehtimäki, Terho; Li, Man; Lieb, Wolfgang; Lind, Lars; Lindgren, Cecilia M.; Loos, Ruth J.F.; Lukas, Mary Ann; Lyytikäinen, Leo-Pekka; Mahajan, Anubha; Matias-Garcia, Pamela R.; Meisinger, Christa; Meitinger, Thomas; Melander, Olle; Milaneschi, Yuri; Mishra, Pashupati P.; Mononen, Nina; Morris, Andrew P.; Mychaleckyj, Josyf C.; Nadkarni, Girish N.; Naito, Mariko; Nakatochi, Masahiro; Nalls, Mike A.; Nauck, Matthias; Nikus, Kjell; Ning, Boting; Nolte, Ilja M.; Nutile, Teresa; O'Donoghue, Michelle L.; O'Connell, Jeffrey; Olafsson, Isleifur; Orho-Melander, Marju; Parsa, Afshin; Pendergrass, Sarah A.; Penninx, Brenda W.J.H.; Pirastu, Mario; Preuss, Michael H.; Psaty, Bruce M.; Raffield, Laura M.; Raitakari, Olli T.; Rheinberger, Myriam; Rice, Kenneth M.; Rizzi, Federica; Rosenkranz, Alexander R.; Rossing, Peter; Rotter, Jerome I.; Ruggiero, Daniela; Ryan, Kathleen A.; Sabanayagam, Charumathi; Salvi, Erika; Schmidt, Helena; Schmidt, Reinhold; Scholz, Markus; Schöttker, Ben; Schulz, Christina-Alexandra; Sedaghat, Sanaz; Shaffer, Christian M.; Sieber, Karsten B.; Sim, Xueling; Sims, Mario; Snieder, Harold; Stanzick, Kira J.; Thorsteinsdottir, Unnur; Stocker, Hannah; Strauch, Konstantin; Stringham, Heather M.; Sulem, Patrick; Szymczak, Silke; Taylor, Kent D.; Thio, Chris H.L.; Tremblay, Johanne; Vaccargiu, Simona; van der Harst, Pim; van der Most, Peter J.; Verweij, Niek; Völker, Uwe; Wakai, Kenji; Waldenberger, Melanie; Wallentin, Lars; Wallner, Stefan; Wang, Judy; Waterworth, Dawn M.; White, Harvey D.; Willer, Cristen J.; Wong, Tien-Yin; Woodward, Mark; Yang, Qiong; Yerges-Armstrong, Laura M.; Zimmermann, Martina; Zonderman, Alan B.; Bergler, Tobias; Stefansson, Kari; Böger, Carsten A.; Pattaro, Cristian; Köttgen, Anna; Kronenberg, Florian; Heid, Iris M. (Peer reviewed; Journal article, 2022)
      Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies ...

    • Genetic nurture versus genetic transmission of risk for ADHD traits in the Norwegian Mother, Father and Child Cohort Study 

      Pingault, Jean-Baptiste; Barkhuizen, Wikus; Wang, Biyao; Hannigan, Laurie John; Eilertsen, Espen Moen; Corfield, Elizabeth Claire; Andreassen, Ole; Ask, Helga; Tesli, Martin Steen; Askeland, Ragna Bugge; Davey Smith, George; Stoltenberg, Camilla; Davies, Neil M.; Reichborn-Kjennerud, Ted; Ystrøm, Eivind; Havdahl, Alexandra (Peer reviewed; Journal article, 2022)
      Identifying mechanisms underlying the intergenerational transmission of risk for attention-deficit/hyperactivity disorder (ADHD) traits can inform interventions and provide insights into the role of parents in shaping their ...

    • The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan running title: Genetics of subcortical lifespan change 

      Fjell, Anders Martin; Grydeland, Håkon; Wang, Yunpeng; Amlien, Inge; Bartrés-Faz, David; Brandmaier, Andreas M.; Düzel, Sandra; Elman, Jeremy; Franz, Carol; Håberg, Asta; Kietzmann, Tim C.; Kievit, Rogier A.; Kremen, William S.; Krogsrud, Stine Kleppe; Kühn, Simone; Lindenberger, Ulman; Macià, Didac; Mowinckel, Athanasia Monika; Nyberg, Lars; Panizzon, Matthew S.; Solé-Padullés, Cristina; Sørensen, Øystein; Westerhausen, Rene; Walhovd, Kristine B (Peer reviewed; Journal article, 2021)
      Development and aging of the cerebral cortex show similar topographic organization and are governed by the same genes. It is unclear whether the same is true for subcortical regions, which follow fundamentally different ...

    • Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes 

      Drange, Ole Kristian; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Finseth, Per Ivar; Witoelar, Aree; Frei, Oleksandr; Wang, Yunpeng; Hassani, Sahar; Djurovic, Srdjan; Dale, Anders M; Andreassen, Ole Andreas (Journal article; Peer reviewed, 2019)
      Background: Alzheimer’s disease (AD) and bipolar disorder (BIP) are complex traits influenced by numerous common genetic variants, most of which remain to be detected. Clinical and epidemiological evidence suggest that AD ...