Blar i Publikasjoner fra CRIStin - NTNU på tittel

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    • DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates 

      Rasmussen, Erik; Vågbø, Cathrine Broberg; Münch, Daniel; Krokan, Hans Einar; Klungland, Arne; Amdam, Gro Vang; Dahl, John Arne (Journal article; Peer reviewed, 2016)
      Well-known epigenetic DNA modifications in mammals include the addition of a methyl group and a hydroxyl group to cytosine, resulting in 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) respectively. In contrast, ...

    • DNA compaction induced by a cationic polymer or surfactant impact gene expression and DNA degradation 

      Ainalem, Marie-Louise; Bartles, Andrew; Muck, Joscha; Dias, Rita de Sousa; Carnerup, Anna M.; Zink, Daniele; Nylander, Tommy (Journal article; Peer reviewed, 2014)
      There is an increasing interest in achieving gene regulation in biotechnological and biomedical applications by using synthetic DNA-binding agents. Most studies have so far focused on synthetic sequence-specific DNA-binding ...

    • DNA Condensation by Peptide-Conjugated PAMAM Dendrimers. Influence of Peptide Charge 

      Dannert, Corinna; Mardal, Ingrid; Lale, Rahmi; Stokke, Bjørn Torger; Dias, Rita (Peer reviewed; Journal article, 2023)
      Nucleic acid delivery to cells is an important therapeutic strategy that requires the transport of nucleic acids to intracellular compartments and their protection from enzymatic degradation. This can be achieved through ...

    • DNA double-strand breaks in relation to persistent organic pollutants in a fasting seabird 

      Fenstad, Anette; Jenssen, Bjørn Munro; Moe, Børge; Hanssen, Sveinn Are; Bingham, Christopher George; Herzke, Dorte; Bustnes, Jan Ove; Krøkje, Åse (Journal article; Peer reviewed, 2014)
      Lipophilic persistent organic pollutants (POPs) are released from fat reserves during fasting, causing increased blood concentrations. Thus, POPs represent a potential anthropogenic stressor during fasting periods. We ...

    • DNA double‐strand breaks in Arctic char (Salvelinus alpinus) from Bjørnøya in the Norwegian Arctic 

      Neerland, Eirik D.; Bytingsvik, Jenny; Nikiforov, Vladimir; Evenset, Anita; Krøkje, Åse (Journal article; Peer reviewed, 2019)
      High levels of organochlorine contaminants (OCs) have been found in arctic char (Salvelinus alpinus) from Lake Ellasjøen, Bjørnøya (Norwegian Arctic). The aim of the present study was to investigate the potential genotoxic ...

    • DNA glycosylase Neil2 contributes to genomic responses in the spleen during clinical prion disease 

      Scheffler, Katja; Jalland, Clara Maria Osnes; Benestad, Sylvie L.; Moldal, Torfinn; Ersdal, Cecilie; Gunnes, Gjermund; Suganthan, Rajikala; Bjørås, Magnar; Tranulis, Michael A. (Peer reviewed; Journal article, 2020)
      The DNA glycosylase Neil2 is a member of the base excision repair (BER) family of enzymes, which are important for repair of oxidative DNA damage. Specifically, Neil2 participates in repair of oxidized bases in single-stranded ...

    • DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development 

      Quiles-Jiménez, Ana M T; Gregersen, Ida; Segers, Filip; Skarpengland, Tonje; Kroustallaki, Pinelopi; Yang, Kuan; Kong, Xiang Yi; Lauritzen, Knut Husø; Olsen, Maria Belland; Karlsen, Tom Rune; Nyman, Tuula Anneli; Sagen, Ellen Lund; Bjerkeli, Vigdis; Suganthan, Rajikala; Nygård, Ståle; Scheffler, Katja; Prins, Jurriën; Van der Veer, Eric; Øgaard, Jonas; Fløisand, Yngvar; Jørgensen, Helle F.; Holven, Kirsten Bjørklund; Biessen, Erik A.L.; Nilsen, Hilde; Dahl, Tuva Børresdatter; Holm, Sverre; Bennett, Martin R.; Aukrust, Pål; Bjørås, Magnar; Halvorsen, Bente (Peer reviewed; Journal article, 2021)
      Background and aims Atherogenesis involves a complex interaction between immune cells and lipids, processes greatly influenced by the vascular smooth muscle cell (VSMC) phenotype. The DNA glycosylase NEIL3 has previously ...

    • DNA hydroxymethylation differences underlie phenotypic divergence of somatic growth in Nile tilapia reared in common garden 

      Konstantinidis, Ioannis; Sætrom, Pål; Brieuc, Marine Servane Ono; Jakobsen, Kjetill Sigurd; Liedtke, Hannes; Pohlmann, Caroline; Tsoulia, Thomais; Fernandes, Jorge Manuel de Oliveira (Journal article; Peer reviewed, 2023)
      Phenotypic plasticity of metabolism and growth are essential for adaptation to new environmental conditions, such as those experienced during domestication. Epigenetic regulation plays a key role in this process but the ...

    • DNA hypermethylation associated with upregulated gene expression in prostate cancer demonstrates the diversity of epigenetic regulation 

      Rauluseviciute, Ieva; Drabløs, Finn; Rye, Morten Beck (Journal article; Peer reviewed, 2020)
      Background Prostate cancer (PCa) has the highest incidence rates of cancers in men in western countries. Unlike several other types of cancer, PCa has few genetic drivers, which has led researchers to look for additional ...

    • DNA metabarcoding adds valuable information for management of biodiversity in roadside stormwater ponds 

      Sun, Zhenhua; Majaneva, Markus; Sokolova, Ekaterina; Rauch, Sébastien; Meland, Sondre; Ekrem, Torbjørn (Journal article; Peer reviewed, 2019)
      Stormwater ponds are used to compensate for the adverse effects that road runoff might have on the natural environment. Depending on their design and placement, stormwater ponds can act as both refugia and traps for local ...

    • DNA metabarcoding and spatial modelling link diet diversification with distribution homogeneity in European bats 

      Alberdi, Antton; Razgour, Orly; Aizpurua, Ostaizka; Novella-Fernandez, Roberto; Aihartza, Joxerra; Budinski, Ivana; Garin, Inazio; Ibáñez, Carlos; Izagirre, Eñaut; Rebelo, Hugo; Russo, Danilo; Vlaschenko, Anton; Zhelyazkova, Violeta; Zrncic, Vida; Gilbert, Marcus Thomas Pius (Peer reviewed; Journal article, 2020)
      Inferences of the interactions between species’ ecological niches and spatial distribution have been historically based on simple metrics such as low-resolution dietary breadth and range size, which might have impeded the ...

    • DNA Metabarcoding of Preservative Ethanol Reveals Changes in Invertebrate Community Composition Following Rotenone Treatment 

      Kjærstad, Gaute; Majaneva, Markus; Falahati-Anbaran, Mohsen; Topstad, Lasse; Finstad, Anders Gravbrøt; Arnekleiv, Jo Vegar; Ekrem, Torbjørn (Peer reviewed; Journal article, 2022)
      The botanical compound rotenone is extensively used to eradicate populations and reduce the negative impacts of freshwater invasive animals. The method is controversial as non-target organisms often are negatively affected, ...

    • DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival 

      Pedersen, Christine Aaserød; Cao, Maria Dung; Fleischer, Thomas; Rye, Morten Beck; Knappskog, Stian; Eikesdal, Hans Petter; Lønning, Per Eystein; Tost, Jörg; Kristensen, Vessela N.; Tessem, May-Britt; Giskeødegård, Guro F.; Bathen, Tone Frost (Peer reviewed; Journal article, 2022)
      Background Locally advanced breast cancer is a heterogeneous disease with respect to response to neoadjuvant chemotherapy (NACT) and survival. It is currently not possible to accurately predict who will benefit from the ...

    • DNA methylation data by sequencing: experimental approaches and recommendations for tools and pipelines for data analysis 

      Rauluseviciute, Ieva; Drabløs, Finn; Rye, Morten Beck (Journal article; Peer reviewed, 2019)
      Sequencing technologies have changed not only our approaches to classical genetics, but also the field of epigenetics. Specific methods allow scientists to identify novel genome-wide epigenetic patterns of DNA methylation ...

    • DNA methylation-based age acceleration observed in IDH wild-type glioblastoma is associated with better outcome-including in elderly patients 

      Bady, Pierre; Marosi, Christine; Weller, Michael; Grønberg, Bjørn Henning; Schultz, Henrik; Taphoorn, Martin J B; Gijtenbeek, Johanna M M; van den Bent, Martin J.; von Deimling, Andreas; Stupp, Roger; Malmström, Annika; Hegi, Monika E. (Peer reviewed; Journal article, 2022)
      Elderly patients represent a growing proportion of individuals with glioblastoma, who however, are often excluded from clinical trials owing to poor expected prognosis. We aimed at identifying age-related molecular differences ...

    • DNA repair enzyme NEIL3 enables a stable neural representation of space by shaping transcription in hippocampal neurons 

      Kunath, Nicolas; Bugaj, Anna Maria; Bigonah, Pegah; Fernandez Berrocal, Marion Silvana; Bjørås, Magnar; Ye, Jing (Peer reviewed; Journal article, 2021)
      DNA repair enzymes are essential for the maintenance of the neuronal genome and thereby proper brain functions. Emerging evidence links DNA repair to epigenetic gene regulation; however, its contribution to different ...

    • DNA Repair Mechanisms are Activated in Circulating Lymphocytes of Hospitalized Covid-19 Patients 

      Olsen, Maria Belland; Huse, Camilla; Sousa, Mirta; Murphy, Sarah Louise Mikalsen; Sarno, Antonio; Obermann, Tobias Sebastian; Yang, Kuan; Holter, Jan Cato; Jørgensen, Marthe Jøntvedt; Christensen, Erik Egeland; Wang, Wei; Ji, Ping; Heggelund, Lars; Hoel, Hedda; Dyrhol-Riise, Anne Ma; Gregersen, Ida; Aukrust, Pål; Bjørås, Magnar; Halvorsen, Bente; Dahl, Tuva Børresdatter (Peer reviewed; Journal article, 2022)
      Purpose: Reactive oxygen species (ROS) are an important part of the inflammatory response during infection but can also promote DNA damage. Due to the sustained inflammation in severe Covid-19, we hypothesized that ...

    • DNA Sequencing Historical Lichen Specimens 

      Kistenich, Sonja; Halvorsen, Rune; Schrøder-Nielsen, Audun; Thorbek, Birgitte Lisbeth Graae; Timdal, Einar; Bendiksby, Mika (Journal article; Peer reviewed, 2019)
      Biological specimens in natural history collections worldwide are increasingly being used in biogeographical, environmental, and taxonomic studies. For their meaningful use, correct species identification is crucial. For ...

    • DNA topoisomerase IIα and mitosin expression predict meningioma recurrence better than histopathological grade and MIB-1 after initial surgery 

      Winther, Theo L.; Torp, Sverre Helge (Journal article; Peer reviewed, 2017)
      Background: The 2016 WHO histopathological grade or conventional biomarker MIB-1 is insufficient for predicting meningioma recurrence after initial treatment and alternative strategies are required. In this study, we ...

    • DNA walks in virus genomics 

      Belinsky, Alexandra; Kouzaev, Guennadi (Journal article; Peer reviewed, 2024)
      This paper studies published results in imaging and digital processing of virus RNAs (ribonucleic acid) using DNA (deoxyribonucleic acid) walks. The complicated nature and physicochemical properties of these nucleotide ...