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Genome scale transcriptional response diversity among ten ecotypes of Arabidopsis thaliana during heat stress
(Journal article; Peer reviewed, 2013) -
The genome sequence of the grey wolf, Canis lupus Linnaeus 1758
(Peer reviewed; Journal article, 2021)We present a genome assembly from an individual male Canis lupus orion (the grey wolf, subspecies: Greenland wolf; Chordata; Mammalia; Carnivora; Canidae). The genome sequence is 2,447 megabases in span. The majority of ... -
The genome sequence of the killer whale, Orcinus orca (Linnaeus, 1758)
(Peer reviewed; Journal article, 2022)We present a genome assembly from an individual female Orcinus orca (the killer whale; Chordata; Mammalia; Artiodactyla; Delphinidae). The genome sequence is 2.65 gigabases in span. The majority of the assembly (93.76%) ... -
Genome wide association study of response to interval and continuous exercise training: the Predict-HIIT study
(Peer reviewed; Journal article, 2021)Background Low cardiorespiratory fitness (V̇O2peak) is highly associated with chronic disease and mortality from all causes. Whilst exercise training is recommended in health guidelines to improve V̇O2peak, there is ... -
Genome-based genetic tool development for Bacillus methanolicus: Theta-and rolling circle-replicating plasmids for inducible gene expression and application to methanol-based cadaverine production
(Peer reviewed; Journal article, 2016)Bacillus methanolicus is a thermophilic methylotroph able to overproduce amino acids from methanol, a substrate not used for human or animal nutrition. Based on our previous RNA-seq analysis a mannitol inducible promoter ... -
Genome-culture coevolution drives rapid divergence in the killer whale
(Journal article; Peer reviewed, 2016)Analysing population genomic data from killer whale ecotypes, which we estimate have globally radiated within less than 250,000 years, we show that genetic structuring including the segregation of potentially functional ... -
Genome-level transcription data of Yersinia pestis analyzed with a New metabolic constraint-based approach
(Journal article; Peer reviewed, 2012)Background: Constraint-based computational approaches, such as flux balance analysis (FBA), have proven successful in modeling genome-level metabolic behavior for conditions where a set of simple cellular objectives can ... -
Genome-resolved metagenomics suggests a mutualistic relationship between Mycoplasma and salmonid hosts
(Peer reviewed; Journal article, 2021)Salmonids are important sources of protein for a large proportion of the human population. Mycoplasma species are a major constituent of the gut microbiota of salmonids, often representing the majority of microbiota. Despite ... -
Genome-scale cold stress response regulatory networks in ten Arabidopsis thaliana ecotypes
(Journal article; Peer reviewed, 2013)Background Low temperature leads to major crop losses every year. Although several studies have been conducted focusing on diversity of cold tolerance level in multiple phenotypically divergent Arabidopsis thaliana (A. ... -
Genome-scale metabolic modelling when changes in environmental conditions affect biomass composition
(Peer reviewed; Journal article, 2021)Genome-scale metabolic modeling is an important tool in the study of metabolism by enhancing the collation of knowledge, interpretation of data, and prediction of metabolic capabilities. A frequent assumption in the use ... -
Genome-scale metabolic models reveal determinants of phenotypic differences in non-Saccharomyces yeasts
(Peer reviewed; Journal article, 2023)Background - Use of alternative non-Saccharomyces yeasts in wine and beer brewing has gained more attention the recent years. This is both due to the desire to obtain a wider variety of flavours in the product and to reduce ... -
Genome-scale reconstructions to assess metabolic phylogeny and organism clustering
(Peer reviewed; Journal article, 2020)Approaches for systematizing information of relatedness between organisms is important in biology. Phylogenetic analyses based on sets of highly conserved genes are currently the basis for the Tree of Life. Genome-scale ... -
Genome-wide analysis identifies impaired axonogenesis in chronic overlapping pain conditions
(Peer reviewed; Journal article, 2021)Chronic pain is often present at more than one anatomical location, leading to chronic overlapping pain conditions (COPC). Whether COPC represents a distinct pathophysiology from the occurrence of pain at only one site is ... -
Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles
(Peer reviewed; Journal article, 2022)Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified ... -
Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders
(Peer reviewed; Journal article, 2021)Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for ... -
Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease
(Peer reviewed; Journal article, 2021)Objective Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the population but its aetiology, including suspected genetic predisposition, is poorly understood. We report the first genome-wide ... -
Genome-wide analysis of the oxyntic proliferative isthmus zone reveals ASPM as a possible gastric stem/progenitor cell marker overexpressed in cancer.
(Journal article; Peer reviewed, 2015)The oxyntic proliferative isthmus zone contains the main stem/progenitor cells that provide for physiological renewal of the distinct mature cell lineages in the oxyntic epithelium of the stomach. These cells are also ... -
Genome-wide analysis yields new loci associating with aortic valve stenosis
(Journal article; Peer reviewed, 2018)Aortic valve stenosis (AS) is the most common valvular heart disease, and valve replacement is the only definitive treatment. Here we report a large genome-wide association (GWA) study of 2,457 Icelandic AS cases and 349,342 ... -
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
(Peer reviewed; Journal article, 2022)Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry ... -
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes
(Journal article; Peer reviewed, 2019)Excessive daytime sleepiness (EDS) affects 10–20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 individuals from ...