dc.contributor.author | Abdollahi, Pegah | |
dc.contributor.author | Köhn, Maja | |
dc.contributor.author | Børset, Magne | |
dc.date.accessioned | 2021-03-22T10:28:40Z | |
dc.date.available | 2021-03-22T10:28:40Z | |
dc.date.created | 2021-01-05T12:28:22Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0304-3835 | |
dc.identifier.uri | https://hdl.handle.net/11250/2734767 | |
dc.description.abstract | Many cell signaling pathways are activated or deactivated by protein tyrosine phosphorylation and dephosphorylation, catalyzed by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), respectively. Even though PTPs are as important as PTKs in this process, their role has been neglected for a long time. Multiple myeloma (MM) is a cancer of plasma cells, which is characterized by production of monoclonal immunoglobulin, anemia and destruction of bone. MM is still incurable with high relapse frequency after treatment. In this review, we highlight the PTPs that were previously described in MM or have a role that can be relevant in a myeloma context. Our purpose is to show that despite the importance of PTPs in MM pathogenesis, many unanswered questions in this field need to be addressed. This might help to detect novel treatment strategies for MM patients. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Protein tyrosine phosphatases in multiple myeloma | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.journal | Cancer Letters | en_US |
dc.identifier.doi | 10.1016/j.canlet.2020.11.042 | |
dc.identifier.cristin | 1865499 | |
dc.description.localcode | 0304-3835/© 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |