Higher vitamin B12 levels in neurodevelopmental disorders than in healthy controls and schizophrenia A comparison among participants between 2 and 53 years
dc.contributor.author | Hope, Sigrun | |
dc.contributor.author | Nærland, Terje | |
dc.contributor.author | Høyland, Anne Lise | |
dc.contributor.author | Torske, Tonje | |
dc.contributor.author | Malt, Eva | |
dc.contributor.author | Abrahamsen, Tore G | |
dc.contributor.author | Nerhus, Mari | |
dc.contributor.author | Wedervang-Resell, Kirsten | |
dc.contributor.author | Lonning, Vera Louise Hiorth | |
dc.contributor.author | Johannessen, Jarle | |
dc.contributor.author | Steen, Nils Eiel | |
dc.contributor.author | Agartz, Ingrid | |
dc.contributor.author | Stenberg, Nina | |
dc.contributor.author | Hundhausen, Thomas Eckhard | |
dc.contributor.author | Mørkrid, Lars | |
dc.contributor.author | Andreassen, Ole Andreas | |
dc.date.accessioned | 2021-02-22T12:45:14Z | |
dc.date.available | 2021-02-22T12:45:14Z | |
dc.date.created | 2020-07-20T10:03:55Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | The FASEB Journal. 2020, 34 (6), 8114-8124. | en_US |
dc.identifier.issn | 0892-6638 | |
dc.identifier.uri | https://hdl.handle.net/11250/2729524 | |
dc.description.abstract | Recent studies suggest that both high and low levels of vitamin B12 (vitB12) may have negative health impacts. We measured VitB12 in patients with the Neurodevelopmental disorders (ND) (n = 222), comprised of Autism Spectrum Disorders, specific Developmental disorders, and Intellectual Disability (aged 2‐53 years), schizophrenia (n = 401), and healthy controls (HC) (n = 483). Age‐and gender‐adjusted vitB12 z‐scores were calculated by comparisons with a reference population (n = 76 148). We found higher vitB12 in ND (median 420 pmol/L, mean z‐score: 0.30) than in HC (316 pmol/L, z‐score: 0.06, P < .01) and schizophrenia (306 pmol/L, z‐score: −0.02, P < .001), which was significant after adjusting for age, gender, vitB12 supplement, folate, hemoglobin, leukocytes, liver, and kidney function (P < .02). In ND, 20% (n = 44) had vitB12 above 650 pmol/L, and 1% (n = 3) had below 150 pmol/L (common reference limits). In 6.3% (n = 14) of ND, vitB12 was above 2SD of mean in the age‐and gender‐adjusted reference population, which was more frequent than in HC (n = 8, 1.6%), OR: 4.0, P = .001. Low vitB12 was equally frequent as in HC, and vitB12 z‐scores were equal across the age groups. To conclude, vitB12 was higher in ND than in HC and schizophrenia, suggesting a specific feature of ND, which warrants further studies to investigate the underlying mechanisms. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Federation of American Society of Experimental Biology (FASEB) | en_US |
dc.title | Higher vitamin B12 levels in neurodevelopmental disorders than in healthy controls and schizophrenia A comparison among participants between 2 and 53 years | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | acceptedVersion | en_US |
dc.source.pagenumber | 8114-8124 | en_US |
dc.source.volume | 34 | en_US |
dc.source.journal | The FASEB Journal | en_US |
dc.source.issue | 6 | en_US |
dc.identifier.doi | 10.1096/fj.201900855RRR | |
dc.identifier.cristin | 1819827 | |
dc.relation.project | Norges forskningsråd: 223273 | en_US |
dc.relation.project | Norges forskningsråd: 213694 | en_US |
dc.description.localcode | This article will not be available due to copyright restrictions (c) 2020 by Federation of American Society of Experimental Biology (FASEB) | en_US |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 2 |
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