dc.contributor.author | Christensen, Ane Charlotte | |
dc.contributor.author | Lensjø, Kristian Kinden | |
dc.contributor.author | Lepperød, Mikkel Elle | |
dc.contributor.author | Dragly, Svenn-Arne | |
dc.contributor.author | Sutterud, Hallvard | |
dc.contributor.author | Blackstad, Jan Sigurd | |
dc.contributor.author | Fyhn, Marianne | |
dc.contributor.author | Hafting, Torkel | |
dc.date.accessioned | 2021-02-10T14:18:55Z | |
dc.date.available | 2021-02-10T14:18:55Z | |
dc.date.created | 2021-02-09T14:38:38Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://hdl.handle.net/11250/2727253 | |
dc.description.abstract | Grid cells are part of a widespread network which supports navigation and spatial memory. Stable grid patterns appear late in development, in concert with extracellular matrix aggregates termed perineuronal nets (PNNs) that condense around inhibitory neurons. It has been suggested that PNNs stabilize synaptic connections and long-term memories, but their role in the grid cell network remains elusive. We show that removal of PNNs leads to lower inhibitory spiking activity, and reduces grid cells’ ability to create stable representations of a novel environment. Furthermore, in animals with disrupted PNNs, exposure to a novel arena corrupted the spatiotemporal relationships within grid cell modules, and the stored representations of a familiar arena. Finally, we show that PNN removal in entorhinal cortex distorted spatial representations in downstream hippocampal neurons. Together this work suggests that PNNs provide a key stabilizing element for the grid cell network. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Nature Research | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Perineuronal nets stabilize the grid cell network | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.journal | Nature Communications | en_US |
dc.identifier.doi | 10.1038/s41467-020-20241-w | |
dc.identifier.cristin | 1888167 | |
dc.description.localcode | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |