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dc.contributor.authorJernelv, Ine Larsen
dc.contributor.authorHjelme, Dag Roar
dc.contributor.authorAksnes, Astrid
dc.identifier.citationBiomedical Optics Express. 2020, 11 (7)en_US
dc.description.abstractFast and accurate continuous glucose monitoring is needed in future systems for control of blood glucose levels in type 1 diabetes patients. Direct spectroscopic measurement of glucose in the peritoneal cavity is an attractive alternative to conventional electrochemical sensors placed subcutaneously. We demonstrate the feasibility of fast glucose measurements in peritoneal fluid using a fibre-coupled tuneable mid-infrared quantum cascade laser. Mid-infrared spectra (1200–925 cm−1) of peritoneal fluid samples from pigs with physiological glucose levels (32–426 mg/dL, or 1.8–23.7 mmol/L) were acquired with a tuneable quantum cascade laser employing both transmission and attenuated total reflection (ATR) spectroscopy. Using partial least-squares regression, glucose concentrations were predicted with mean absolute percentage errors (MAPEs) of 8.7% and 12.2% in the transmission and ATR configurations, respectively. These results show that highly accurate concentration predictions are possible with mid-infrared spectroscopy of peritoneal fluid, and represent a first step towards a miniaturised optical sensor for intraperitoneal continuous glucose monitoring.en_US
dc.publisherOSA Publishingen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleInfrared measurements of glucose in peritoneal fluid with a tuneable quantum cascade laseren_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalBiomedical Optics Expressen_US
dc.relation.projectNorges forskningsråd: 248810en_US
dc.relation.projectNorges forskningsråd: 248872en_US
dc.description.localcodePublished by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.en_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal