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dc.contributor.authorKnutsen, Erik
dc.contributor.authorLellahi, Seyed Mohammad
dc.contributor.authorAure, Miriam Ragle
dc.contributor.authorNord, Silje
dc.contributor.authorFismen, Silje
dc.contributor.authorLarsen, Kenneth Bowitz
dc.contributor.authorTellez Gabriel, Marta
dc.contributor.authorHedberg, Annica
dc.contributor.authorBjørklund, Sunniva
dc.contributor.authorBofin, Anna M.
dc.contributor.authorMælandsmo, Gunhild Mari
dc.contributor.authorSørlie, Therese
dc.contributor.authorMortensen, Elin Synnøve
dc.contributor.authorPerander, Maria
dc.identifier.citationScientific Reports. 2020, 10:1277 1-14.en_US
dc.description.abstractThe long non-coding RNA NEAT1 locus is transcribed into two overlapping isoforms, NEAT1_1 and NEAT1_2, of which the latter is essential for the assembly of nuclear paraspeckles. NEAT1 is abnormally expressed in a wide variety of human cancers. Emerging evidence suggests that the two isoforms have distinct functions in gene expression regulation, and recently it was shown that NEAT1_2, but not NEAT1_1, expression predicts poor clinical outcome in cancer. Here, we report that NEAT1_2 expression correlates with HER2-positive breast cancers and high-grade disease. We provide evidence that NEAT1_1 and NEAT1_2 have distinct expression pattern among different intrinsic breast cancer subtypes. Finally, we show that NEAT1_2 expression and paraspeckle formation increase upon lactation in humans, confirming what has previously been demonstrated in mice.en_US
dc.publisherSpringer Natureen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleThe expression of the long NEAT1_2 isoform is associated with human epidermal growth factor receptor 2-positive breast cancersen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalScientific Reportsen_US
dc.description.localcodeOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal