dc.contributor.advisor | Solheim, Ole | nb_NO |
dc.contributor.author | Sagberg, Lisa Millgård | nb_NO |
dc.date.accessioned | 2014-12-19T14:23:00Z | |
dc.date.available | 2014-12-19T14:23:00Z | |
dc.date.created | 2013-08-27 | nb_NO |
dc.date.issued | 2012 | nb_NO |
dc.identifier | 643466 | nb_NO |
dc.identifier.uri | http://hdl.handle.net/11250/264543 | |
dc.description.abstract | Background: There are few studies on the impact of glioma surgery on health-related quality of life (HRQoL). The generic instrument EQ-5D 3L has been utilized in this context, but several questions concerning use and interpretation are unanswered.
Objective: To evaluate the responsiveness of EQ-5D 3L in patients undergoing glioma surgery and estimate the minimal clinically important difference (MID).
Materials and methods: EQ-5D 3L index values from 164 patients who underwent glioma surgery in the period 2007-2012 were analysed. Responsiveness and MID were estimated by using a combination of distribution-based and anchor-based methods. Karnofsky Performance Status (KPS) served as an anchor.
Results: Patients who improved functionally did not report significantly higher EQ-5D 3L scores postoperatively with a Standardized Response Mean (SRM) of 0.04 (p=0.13). Patients who deteriorated functionally reported significantly lower EQ-5D 3L scores postoperative with a SRM of 0.72 (p <0.001). With different approaches we determined a range of MID-values from 0.07 to 0.15.
Conclusions: EQ-5D 3L is responsive to changes when glioma patients are deteriorating functionally after surgery but not responsive when the patients are improving. The MID-values for EQ-5D 3L in glioma surgery are in the upper range of reported MID-values for other conditions. | nb_NO |
dc.language | eng | nb_NO |
dc.publisher | Norges teknisk-naturvitenskapelige universitet, Det medisinske fakultet, Institutt for samfunnsmedisin | nb_NO |
dc.title | Quality of life assessed with EQ-5D 3L in patients undergoing glioma surgery; What is the responsiveness and minimal clinically important difference? | nb_NO |
dc.type | Master thesis | nb_NO |
dc.contributor.department | Norges teknisk-naturvitenskapelige universitet, Det medisinske fakultet, Institutt for samfunnsmedisin | nb_NO |