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dc.contributor.authorWang, Heming
dc.contributor.authorLane, Jacqueline M.
dc.contributor.authorJones, Samuel E.
dc.contributor.authorDashti, Hassan S.
dc.contributor.authorOllila, Hanna M.
dc.contributor.authorWood, Andrew R.
dc.contributor.authorvan Hees, Vincent T.
dc.contributor.authorBrumpton, Ben Michael
dc.contributor.authorWinsvold, Bendik K S
dc.contributor.authorKantojärvi, Katri
dc.contributor.authorPalviainen, Teemu
dc.contributor.authorCade, Brian E.
dc.contributor.authorSofer, Tamar
dc.contributor.authorSong, Yanwei
dc.contributor.authorPatel, Krunal
dc.contributor.authorAnderson, Simon G.
dc.contributor.authorBechtold, David A.
dc.contributor.authorBowden, Jack
dc.contributor.authorEmsley, Richard
dc.contributor.authorKyle, Simon D.
dc.contributor.authorLittle, Max A.
dc.contributor.authorLoudon, Andrew S.
dc.contributor.authorScheer, Frank A.J.L.
dc.contributor.authorPurcell, Shaun M.
dc.contributor.authorRichmond, Rebecca C.
dc.contributor.authorSpiegelhalder, Kai
dc.contributor.authorTyrrell, Jessica
dc.contributor.authorZhu, Xiaofeng
dc.contributor.authorHublin, Christer
dc.contributor.authorKaprio, Jaakko A.
dc.contributor.authorKristiansson, Kati
dc.contributor.authorSulkava, Sonja
dc.contributor.authorPaunio, Tiina
dc.contributor.authorHveem, Kristian
dc.contributor.authorNielsen, Jonas B.
dc.contributor.authorWiller, Cristen J.
dc.contributor.authorZwart, John-Anker
dc.contributor.authorStrand, Linn B
dc.contributor.authorFrayling, Timothy M.
dc.contributor.authorRay, David
dc.contributor.authorLawlor, Deborah A.
dc.contributor.authorRutter, Martin K.
dc.contributor.authorWeedon, Michael N.
dc.contributor.authorRedline, Susan
dc.contributor.authorSaxena, Richa
dc.identifier.citationNature Communications. 2019, 10:3503 1-12.nb_NO
dc.description.abstractExcessive daytime sleepiness (EDS) affects 10–20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 individuals from the UK Biobank, with enrichment for genes expressed in brain tissues and in neuronal transmission pathways. We confirm the aggregate effect of a genetic risk score of 42 SNPs on daytime sleepiness in independent Scandinavian cohorts and on other sleep disorders (restless legs syndrome, insomnia) and sleep traits (duration, chronotype, accelerometer-derived sleep efficiency and daytime naps or inactivity). However, individual daytime sleepiness signals vary in their associations with objective short vs long sleep, and with markers of sleep continuity. The 42 sleepiness variants primarily cluster into two predominant composite biological subtypes - sleep propensity and sleep fragmentation. Shared genetic links are also seen with obesity, coronary heart disease, psychiatric diseases, cognitive traits and reproductive ageing.nb_NO
dc.publisherNature Researchnb_NO
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal
dc.titleGenome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypesnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalNature Communicationsnb_NO
dc.relation.projectStiftelsen Kristian Gerhard Jebsen: SKGJ-MED-015nb_NO
dc.relation.projectNorges forskningsråd: 248817nb_NO
dc.description.localcodeOpen AccessThis article is licensed under a Creative CommonsAttribution 4.0 International License, which permits use, sharing,adaptation, distribution and reproduction in any medium or format, as long as you giveappropriate credit to the original author(s) and the source, provide a link to the CreativeCommons license, and indicate if changes were made. The images or other third partymaterial in this article are included in the article’s Creative Commons license, unlessindicated otherwise in a credit line to the material. If material is not included in thearticle’s Creative Commons license and your intended use is not permitted by statutoryregulation or exceeds the permitted use, you will need to obtain permission directly fromthe copyright holder. To view a copy of this license, visit © The Author(s) 2019nb_NO
cristin.unitnameKlinikk for lunge og arbeidsmedisin
cristin.unitnameInstitutt for samfunnsmedisin og sykepleie

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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal