The Cytoscape BioGateway App: explorative network building from an RDF store

Abstract

The BioGateway App is a Cytoscape (version 3) plugin designed to provide easy query access to the BioGateway Resource Description Framework triple store, which contains functional and interaction information for proteins from several curated resources. For explorative network building, we have added a comprehensive dataset with regulatory relationships of mammalian DNA-binding transcription factors and their target genes, compiled both from curated resources and from a text mining effort. Query results are visualized using the inherent flexibility of the Cytoscape framework, and network links can be checked against curated database records or against the original publication.