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dc.contributor.authorHære, Petter
dc.contributor.authorHøie, Ole Ingebreth
dc.contributor.authorLundin, Knut Erik Aslaksen
dc.contributor.authorHaugeberg, Glenn
dc.date.accessioned2020-01-14T09:44:14Z
dc.date.available2020-01-14T09:44:14Z
dc.date.created2019-11-20T12:48:21Z
dc.date.issued2019
dc.identifier.citationEuropean journal of internal medicine. 2019, 68 23-29.nb_NO
dc.identifier.issn0953-6205
dc.identifier.urihttp://hdl.handle.net/11250/2636131
dc.description.abstractBackground At time of diagnosis, patients with celiac disease (CD) have been shown to have lower bone mineral density (BMD) than healthy controls. It is unclear whether adult patients with CD can regain a normal BMD after treatment with a gluten-free diet (GFD). Methods Patients diagnosed with CD as adults, who had been treated with GFD for a minimum of two years, were examined by dual energy X-ray absorptiometry (DXA) to determine BMD at femoral neck and spine L2-4. Adherence to GFD was measured using the Celiac Disease Adherence Test (CDAT) scoring tool. Results 143 CD patients underwent DXA assessment, mean age was 55.8 years and mean treatment duration was 9.3 years. 67% of the patients were women, and 51% of these were postmenopausal. The prevalence of low bone mass (Z-score ≤ −1.0) was 18.2% (95%CI: 12.7–25.3%) at femoral neck and 23.1% (95%CI: 16.9–30.6%) at spine L2-4. An increase in low bone density prevalence at spine L2-4 compared to the expected prevalence (p = 0.016) was limited to the postmenopausal women. In a multiple regression analysis, only postmenopausal status and poor adherence to GFD was independently associated with reduced bone density, this however limited to spine L2-4. Conclusion Our study shows a small increase in the prevalence of low bone density at lumbar spine limited to the postmenopausal women. The main finding is that the majority of the CD patients after two years of treatment with GFD had a normal bone density when adjusted for age, gender, ethnicity and weight.nb_NO
dc.language.isoengnb_NO
dc.publisherElseviernb_NO
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.titleNo major reduction in bone mineral density after long-term treatment of patients with Celiac Diseasenb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber23-29nb_NO
dc.source.volume68nb_NO
dc.source.journalEuropean journal of internal medicinenb_NO
dc.identifier.doi10.1016/j.ejim.2019.07.024
dc.identifier.cristin1749881
dc.description.localcode© 2019. This is the authors’ accepted and refereed manuscript to the article. Locked until 8.8.2020 due to copyright restrictions. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/nb_NO
cristin.unitcode194,65,30,0
cristin.unitnameInstitutt for nevromedisin og bevegelsesvitenskap
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1


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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
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