dc.contributor.author | Hære, Petter | |
dc.contributor.author | Høie, Ole Ingebreth | |
dc.contributor.author | Lundin, Knut Erik Aslaksen | |
dc.contributor.author | Haugeberg, Glenn | |
dc.date.accessioned | 2020-01-14T09:44:14Z | |
dc.date.available | 2020-01-14T09:44:14Z | |
dc.date.created | 2019-11-20T12:48:21Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | European journal of internal medicine. 2019, 68 23-29. | nb_NO |
dc.identifier.issn | 0953-6205 | |
dc.identifier.uri | http://hdl.handle.net/11250/2636131 | |
dc.description.abstract | Background
At time of diagnosis, patients with celiac disease (CD) have been shown to have lower bone mineral density (BMD) than healthy controls. It is unclear whether adult patients with CD can regain a normal BMD after treatment with a gluten-free diet (GFD).
Methods
Patients diagnosed with CD as adults, who had been treated with GFD for a minimum of two years, were examined by dual energy X-ray absorptiometry (DXA) to determine BMD at femoral neck and spine L2-4. Adherence to GFD was measured using the Celiac Disease Adherence Test (CDAT) scoring tool.
Results
143 CD patients underwent DXA assessment, mean age was 55.8 years and mean treatment duration was 9.3 years. 67% of the patients were women, and 51% of these were postmenopausal. The prevalence of low bone mass (Z-score ≤ −1.0) was 18.2% (95%CI: 12.7–25.3%) at femoral neck and 23.1% (95%CI: 16.9–30.6%) at spine L2-4. An increase in low bone density prevalence at spine L2-4 compared to the expected prevalence (p = 0.016) was limited to the postmenopausal women. In a multiple regression analysis, only postmenopausal status and poor adherence to GFD was independently associated with reduced bone density, this however limited to spine L2-4.
Conclusion
Our study shows a small increase in the prevalence of low bone density at lumbar spine limited to the postmenopausal women. The main finding is that the majority of the CD patients after two years of treatment with GFD had a normal bone density when adjusted for age, gender, ethnicity and weight. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Elsevier | nb_NO |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | No major reduction in bone mineral density after long-term treatment of patients with Celiac Disease | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | acceptedVersion | nb_NO |
dc.source.pagenumber | 23-29 | nb_NO |
dc.source.volume | 68 | nb_NO |
dc.source.journal | European journal of internal medicine | nb_NO |
dc.identifier.doi | 10.1016/j.ejim.2019.07.024 | |
dc.identifier.cristin | 1749881 | |
dc.description.localcode | © 2019. This is the authors’ accepted and refereed manuscript to the article. Locked until 8.8.2020 due to copyright restrictions. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | nb_NO |
cristin.unitcode | 194,65,30,0 | |
cristin.unitname | Institutt for nevromedisin og bevegelsesvitenskap | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 1 | |