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Simple Nonlinear Models for Glucose-Insulin Dynamics: Application to Intraperitoneal Insulin Infusion

Lopez Zazueta, Claudia; Stavdahl, Øyvind; Fougner, Anders Lyngvi
Journal article, Peer reviewed
Published version
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URI
http://hdl.handle.net/11250/2634835
Date
2019
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  • Institutt for teknisk kybernetikk [2240]
  • Publikasjoner fra CRIStin - NTNU [20842]
Original version
IFAC-PapersOnLine. 2019, 52 (26), 219-224.   10.1016/j.ifacol.2019.12.261
Abstract
The design of a model-based control method for an Artificial Pancreas requires a relatively simple and identifiable mathematical model to control glucose levels through hormone delivery. In this work we introduce new, simple nonlinear models to simulate data from experiments where insulin boluses are administrated in the peritoneal cavity. The models account for the delay between insulin administration and its nonlinear transport to other compartments. They were calibrated using experimental data from pigs. The results show that the suggested models are able to describe the data well, with average BIC value of 145. Moreover, the new models were compared with a common linear model which was not able to describe the data well, with BIC value of 920. They were also compared with a common nonlinear model which failed to represent insulin increases in the data and had BIC value of 637. Finally, profile likelihoods were applied for assessing the identifiability of one of the new models.
Publisher
International Federation of Automatic Control (IFAC)
Journal
IFAC-PapersOnLine

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