dc.contributor.author | Aasly, Jan | |
dc.contributor.author | Johansen, Krisztina | |
dc.contributor.author | Brønstad, Gunnar | |
dc.contributor.author | Warø, Bjørg Johanne | |
dc.contributor.author | Majbour, NK | |
dc.contributor.author | Varghese, S | |
dc.contributor.author | Alzahmi, F | |
dc.contributor.author | Paleologou, KE | |
dc.contributor.author | Amer, DAM | |
dc.contributor.author | Al-Hayani, A | |
dc.contributor.author | El-Agnaf, OMA | |
dc.date.accessioned | 2019-11-07T07:11:13Z | |
dc.date.available | 2019-11-07T07:11:13Z | |
dc.date.created | 2014-11-21T14:34:57Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Frontiers in Aging Neuroscience. 2014, 6, . | nb_NO |
dc.identifier.issn | 1663-4365 | |
dc.identifier.uri | http://hdl.handle.net/11250/2627057 | |
dc.description.abstract | Mutations in the leucine-rich repeat kinase 2 gene are the most common cause of autosomal dominant Parkinson’s disease (PD). To assess the cerebrospinal fluid (CSF) levels of α-synuclein oligomers in symptomatic and asymptomatic leucine-rich repeat kinase 2 mutation carriers, we used enzyme-linked immunosorbent assays (ELISA) to investigate total and oligomeric forms of α-synuclein in CSF samples. The CSF samples were collected from 33 Norwegian individuals with leucine-rich repeat kinase 2 mutations: 13 patients were clinically diagnosed with PD and 20 patients were healthy, asymptomatic leucine-rich repeat kinase 2 mutation carriers. We also included 35 patients with sporadic PD (sPD) and 42 age-matched healthy controls. Levels of CSF α-synuclein oligomers were significantly elevated in healthy asymptomatic individuals carrying leucine-rich repeat kinase 2 mutations (n = 20; P < 0.0079) and in sPD group (n = 35; P < 0.003) relative to healthy controls. Increased α-synuclein oligomers in asymptomatic leucine-rich repeat kinase 2 mutation carriers showed a sensitivity of 63.0% and a specificity of 74.0%, with an area under the curve of 0.66, and a sensitivity of 65.0% and a specificity of 83.0%, with an area under the curve of 0.74 for sPD cases. An inverse correlation between CSF levels of α- synuclein oligomers and disease severity and duration was observed. Our study suggests that quantification of α-synuclein oligomers in CSF has potential value as a tool for PD diagnosis and presymptomatic screening of high-risk individuals. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Frontiers Media | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Elevated levels of cerebrospinal fluid α-synuclein oligomers in healthy asymptomatic LRRK2 mutation carriers | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.volume | 6 | nb_NO |
dc.source.journal | Frontiers in Aging Neuroscience | nb_NO |
dc.identifier.doi | 10.3389/fnagi.2014.00248 | |
dc.identifier.cristin | 1175622 | |
dc.description.localcode | Copyright © 2014 Aasly, Johansen, Brønstad, Warø, Majbour, Varghese, Alzahmi, Paleologou, Amer, Al-Hayani and El-Agnaf. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | nb_NO |
cristin.unitcode | 1920,16,0,0 | |
cristin.unitcode | 194,65,30,0 | |
cristin.unitname | Nevroklinikken | |
cristin.unitname | Institutt for nevromedisin og bevegelsesvitenskap | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |