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dc.contributor.authorBukhari, Syed Majid
dc.contributor.authorFeuerherm, Astrid Jullumstrø
dc.contributor.authorBoulfrad, Fayssal
dc.contributor.authorZlatkovic, Bojan
dc.contributor.authorJohansen, Berit
dc.contributor.authorSimic, Nebojsa
dc.date.accessioned2019-11-01T08:43:50Z
dc.date.available2019-11-01T08:43:50Z
dc.date.created2014-03-06T12:49:16Z
dc.date.issued2014
dc.identifier.citationJournal of the Serbian Chemical Society. 2014, 79 (7), 779-791.nb_NO
dc.identifier.issn0352-5139
dc.identifier.urihttp://hdl.handle.net/11250/2626036
dc.description.abstractThe plant Sclerochloa dura is traditionally used in South-East Serbia to treat menstrual disorders characterized by pain and excessive bleeding. According to subjects’ statements, a reduction in bleeding and pain is experienced shortly after oral intake. The focus of this investigation was to determine the inhibitory effects of the plant on the arachidonic acid (AA) cascade alongwith the spectrophotometric determination of antioxidant capacity. The AA release assay was performed using the human fibroblastlike synoviocyte cell line SW982 to determine the AA release and hence phospholipase A2 (PLA2) activity. The crude extract and subsequent fractions of S. dura inhibit IL-1 induced release of AA in a time- and dose-dependent manner in SW982 cells. The IC50 for the crude extract is 1.5 mg/mL at 4 h and 24 h of stimulation. Treating the cells with 0.22, 0.11 and 0.06 mg/mL of methanolic fraction resulted in 97%, 91%, and 63% inhibition of AA-release, respectively. One milligram of the crude extract contained 34.78 μg pyrocatechol equivalent phenolic content, 22.80 μg quercetin equivalent flavonoid content and antioxidant activity of 70.11 μg α-tocopherol equivalents. Strong inhibitory effects of the S. dura extracts on AA cascade may explain the reported pain- and discomfort relieving effects.nb_NO
dc.language.isoengnb_NO
dc.publisherNational Library of Serbianb_NO
dc.titleAnti-inflammatory and antioxidant activities of Sclerochloa dura (Poaceae)nb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber779-791nb_NO
dc.source.volume79nb_NO
dc.source.journalJournal of the Serbian Chemical Societynb_NO
dc.source.issue7nb_NO
dc.identifier.doi10.2298/JSC131202003B
dc.identifier.cristin1120616
dc.description.localcodeOpen Access.nb_NO
cristin.unitcode194,66,25,0
cristin.unitcode194,66,10,0
cristin.unitnameInstitutt for kjemi
cristin.unitnameInstitutt for biologi
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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