dc.contributor.author | Taylor, Amy E | |
dc.contributor.author | Morris, Richard W | |
dc.contributor.author | Fluharty, Meg | |
dc.contributor.author | Bjørngaard, Johan Håkon | |
dc.contributor.author | Åsvold, Bjørn Olav | |
dc.contributor.author | Gabrielsen, Maiken Elvestad | |
dc.contributor.author | Campbell, A. | |
dc.contributor.author | Marioni, Riccardo R. | |
dc.contributor.author | Kumari, Meena | |
dc.contributor.author | Hällfors, Jenni | |
dc.contributor.author | Männistö, Satu | |
dc.contributor.author | Marques-Vidal, Pedro | |
dc.contributor.author | Kaakinen, Marika | |
dc.contributor.author | Cavadino, Alana | |
dc.contributor.author | Postmus, Iris | |
dc.contributor.author | Husemoen, Lise Lotte N | |
dc.contributor.author | Skaaby, Tea | |
dc.contributor.author | Ahluwalia, Tarunveer Singh | |
dc.contributor.author | Treur, Jorien L | |
dc.contributor.author | Willemsen, Gonneke | |
dc.contributor.author | Dale, Caroline | |
dc.contributor.author | Wannamethee, SG | |
dc.contributor.author | Lahti, J | |
dc.contributor.author | Palotie, Aarno | |
dc.contributor.author | Räikkönen, K | |
dc.contributor.author | Kisialiou, Aliaksei | |
dc.contributor.author | McConnachie, Alex | |
dc.contributor.author | Padmanabhan, Sandosh | |
dc.contributor.author | Wong, Andrew | |
dc.contributor.author | Dalgård, Christine | |
dc.contributor.author | Paternoster, Lavinia | |
dc.contributor.author | Ben-Shlomo, Yoav | |
dc.contributor.author | Tyrrell, Jessica | |
dc.contributor.author | Horwood, John | |
dc.contributor.author | Fergusson, D | |
dc.contributor.author | Kennedy, Martin A | |
dc.contributor.author | Frayling, T | |
dc.contributor.author | Nohr, Ellen A | |
dc.contributor.author | Christiansen, Lene | |
dc.contributor.author | Ohm Kyvik, K | |
dc.contributor.author | Kuh, Diana | |
dc.contributor.author | Watt, Graham | |
dc.contributor.author | Eriksson, Johan | |
dc.contributor.author | Whincup, Peter H | |
dc.contributor.author | Vink, JM | |
dc.contributor.author | Boomsma, Dorret I | |
dc.contributor.author | Davey Smith, George | |
dc.contributor.author | Lawlor, Debbie A | |
dc.contributor.author | Linneberg, Allan | |
dc.contributor.author | Ford, Ian | |
dc.contributor.author | Jukema, J Wouter | |
dc.contributor.author | Power, C | |
dc.contributor.author | Hyppönen, E | |
dc.contributor.author | Jarvelin, Marjo-Riitta | |
dc.contributor.author | Preisig, Martin | |
dc.contributor.author | Borodulin, Katja | |
dc.contributor.author | Kaprio, Jaakko | |
dc.contributor.author | Kivimaki, Mika | |
dc.contributor.author | Smith, BH | |
dc.contributor.author | Hayward, Caroline | |
dc.contributor.author | Romundstad, Pål Richard | |
dc.contributor.author | Sørensen, Thorkild I.A. | |
dc.contributor.author | Munafo, Marcus R | |
dc.contributor.author | Sattar, Naveed | |
dc.date.accessioned | 2019-10-31T06:58:21Z | |
dc.date.available | 2019-10-31T06:58:21Z | |
dc.date.created | 2015-01-02T12:12:30Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | PLoS Genetics. 2014, 10 (12) | nb_NO |
dc.identifier.issn | 1553-7390 | |
dc.identifier.uri | http://hdl.handle.net/11250/2625485 | |
dc.description.abstract | We previously used a single nucleotide polymorphism (SNP) in the CHRNA5-A3-B4 gene cluster associated with heaviness of smoking within smokers to confirm the causal effect of smoking in reducing body mass index (BMI) in a Mendelian randomisation analysis. While seeking to extend these findings in a larger sample we found that this SNP is associated with 0.74% lower body mass index (BMI) per minor allele in current smokers (95% CI -0.97 to -0.51, P = 2.00×10−10), but also unexpectedly found that it was associated with 0.35% higher BMI in never smokers (95% CI +0.18 to +0.52, P = 6.38×10−5). An interaction test confirmed that these estimates differed from each other (P = 4.95×10−13). This difference in effects suggests the variant influences BMI both via pathways unrelated to smoking, and via the weight-reducing effects of smoking. It would therefore be essentially undetectable in an unstratified genome-wide association study of BMI, given the opposite association with BMI in never and current smokers. This demonstrates that novel associations may be obscured by hidden population sub-structure. Stratification on well-characterized environmental factors known to impact on health outcomes may therefore reveal novel genetic associations. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | PLOS, Public Library of Science | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.volume | 10 | nb_NO |
dc.source.journal | PLoS Genetics | nb_NO |
dc.source.issue | 12 | nb_NO |
dc.identifier.doi | 10.1371/journal.pgen.1004799 | |
dc.identifier.cristin | 1189690 | |
dc.description.localcode | Copyright: © 2014 Taylor et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | nb_NO |
cristin.unitcode | 194,65,20,0 | |
cristin.unitcode | 194,65,15,0 | |
cristin.unitname | Institutt for samfunnsmedisin og sykepleie | |
cristin.unitname | Institutt for klinisk og molekylær medisin | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |