Vis enkel innførsel

dc.contributor.authorTaylor, Amy E
dc.contributor.authorMorris, Richard W
dc.contributor.authorFluharty, Meg
dc.contributor.authorBjørngaard, Johan Håkon
dc.contributor.authorÅsvold, Bjørn Olav
dc.contributor.authorGabrielsen, Maiken Elvestad
dc.contributor.authorCampbell, A.
dc.contributor.authorMarioni, Riccardo R.
dc.contributor.authorKumari, Meena
dc.contributor.authorHällfors, Jenni
dc.contributor.authorMännistö, Satu
dc.contributor.authorMarques-Vidal, Pedro
dc.contributor.authorKaakinen, Marika
dc.contributor.authorCavadino, Alana
dc.contributor.authorPostmus, Iris
dc.contributor.authorHusemoen, Lise Lotte N
dc.contributor.authorSkaaby, Tea
dc.contributor.authorAhluwalia, Tarunveer Singh
dc.contributor.authorTreur, Jorien L
dc.contributor.authorWillemsen, Gonneke
dc.contributor.authorDale, Caroline
dc.contributor.authorWannamethee, SG
dc.contributor.authorLahti, J
dc.contributor.authorPalotie, Aarno
dc.contributor.authorRäikkönen, K
dc.contributor.authorKisialiou, Aliaksei
dc.contributor.authorMcConnachie, Alex
dc.contributor.authorPadmanabhan, Sandosh
dc.contributor.authorWong, Andrew
dc.contributor.authorDalgård, Christine
dc.contributor.authorPaternoster, Lavinia
dc.contributor.authorBen-Shlomo, Yoav
dc.contributor.authorTyrrell, Jessica
dc.contributor.authorHorwood, John
dc.contributor.authorFergusson, D
dc.contributor.authorKennedy, Martin A
dc.contributor.authorFrayling, T
dc.contributor.authorNohr, Ellen A
dc.contributor.authorChristiansen, Lene
dc.contributor.authorOhm Kyvik, K
dc.contributor.authorKuh, Diana
dc.contributor.authorWatt, Graham
dc.contributor.authorEriksson, Johan
dc.contributor.authorWhincup, Peter H
dc.contributor.authorVink, JM
dc.contributor.authorBoomsma, Dorret I
dc.contributor.authorDavey Smith, George
dc.contributor.authorLawlor, Debbie A
dc.contributor.authorLinneberg, Allan
dc.contributor.authorFord, Ian
dc.contributor.authorJukema, J Wouter
dc.contributor.authorPower, C
dc.contributor.authorHyppönen, E
dc.contributor.authorJarvelin, Marjo-Riitta
dc.contributor.authorPreisig, Martin
dc.contributor.authorBorodulin, Katja
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorKivimaki, Mika
dc.contributor.authorSmith, BH
dc.contributor.authorHayward, Caroline
dc.contributor.authorRomundstad, Pål Richard
dc.contributor.authorSørensen, Thorkild I.A.
dc.contributor.authorMunafo, Marcus R
dc.contributor.authorSattar, Naveed
dc.identifier.citationPLoS Genetics. 2014, 10 (12)nb_NO
dc.description.abstractWe previously used a single nucleotide polymorphism (SNP) in the CHRNA5-A3-B4 gene cluster associated with heaviness of smoking within smokers to confirm the causal effect of smoking in reducing body mass index (BMI) in a Mendelian randomisation analysis. While seeking to extend these findings in a larger sample we found that this SNP is associated with 0.74% lower body mass index (BMI) per minor allele in current smokers (95% CI -0.97 to -0.51, P = 2.00×10−10), but also unexpectedly found that it was associated with 0.35% higher BMI in never smokers (95% CI +0.18 to +0.52, P = 6.38×10−5). An interaction test confirmed that these estimates differed from each other (P = 4.95×10−13). This difference in effects suggests the variant influences BMI both via pathways unrelated to smoking, and via the weight-reducing effects of smoking. It would therefore be essentially undetectable in an unstratified genome-wide association study of BMI, given the opposite association with BMI in never and current smokers. This demonstrates that novel associations may be obscured by hidden population sub-structure. Stratification on well-characterized environmental factors known to impact on health outcomes may therefore reveal novel genetic associations.nb_NO
dc.publisherPLOS, Public Library of Sciencenb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleStratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokersnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalPLoS Geneticsnb_NO
dc.description.localcodeCopyright: © 2014 Taylor et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.nb_NO
cristin.unitnameInstitutt for samfunnsmedisin og sykepleie
cristin.unitnameInstitutt for klinisk og molekylær medisin

Tilhørende fil(er)


Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Navngivelse 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Navngivelse 4.0 Internasjonal