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dc.contributor.authorTorquati, Luciana
dc.contributor.authorCoombes, Jeff S
dc.contributor.authorMurray, Lydia
dc.contributor.authorHasnain, Sumaira Z
dc.contributor.authorMallard, Alistair R
dc.contributor.authorMcGuckin, Michael A
dc.contributor.authorFassett, Robert G.
dc.contributor.authorCroci, Ilaria
dc.contributor.authorRamos, Joyce S
dc.date.accessioned2019-09-30T07:15:40Z
dc.date.available2019-09-30T07:15:40Z
dc.date.created2019-07-18T18:10:51Z
dc.date.issued2019
dc.identifier.citationNutrients. 2019, 11 (4), 1-10.nb_NO
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/11250/2619266
dc.description.abstractThe positive effects of dietary fibre on gut barrier function and inflammation have not been completely elucidated. Mice studies show gut barrier disruption and diet-induced insulin resistance can be alleviated by cytokine interleukin-22 (IL-22). However, little is known about IL-22 in humans and its association with gut-beneficial nutrients like fibre. We investigated whether fibre intake was associated with circulating levels of IL-22 in 48 participants with metabolic syndrome (MetS). Bivariate analysis was used to explore associations between circulating IL-22, fibre intake, MetS factors, body composition, and cardiorespiratory fitness (peak oxygen uptake, V˙ O2peak). Hierarchical multiple regression (HMR) was used to test the independent association of fibre intake with circulating IL-22, adjusting for variables correlated with IL-22. Circulating IL-22 was positively associated with fibre intake (rs = 0.393, p < 0.006). The HMR-adjusted model explained 40% of circulating IL-22 variability, and fibre intake significantly improved the prediction model by 8.4% (p < 0.022). Participants with fibre intake above median intake of 21.5 g/day had a significantly higher circulating IL-22 than the lower intake group (308.3 ± 454.4 vs. 69.0 ± 106.4 pg/mL, p < 0.019). Fibre intake is independently associated with increased circulating IL-22 in individuals with MetS. Findings warrant further investigations to evaluate whether changes in dietary fibre intake alter circulating IL-22, and its effects on health outcomes.nb_NO
dc.language.isoengnb_NO
dc.publisherMDPInb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleFibre Intake Is Independently Associated with Increased Circulating Interleukin-22 in Individuals with Metabolic Syndromenb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber1-10nb_NO
dc.source.volume11nb_NO
dc.source.journalNutrientsnb_NO
dc.source.issue4nb_NO
dc.identifier.doi10.3390/nu11040815
dc.identifier.cristin1712007
dc.description.localcode© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).nb_NO
cristin.unitcode194,65,25,0
cristin.unitnameInstitutt for sirkulasjon og bildediagnostikk
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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