dc.contributor.author | Torquati, Luciana | |
dc.contributor.author | Coombes, Jeff S | |
dc.contributor.author | Murray, Lydia | |
dc.contributor.author | Hasnain, Sumaira Z | |
dc.contributor.author | Mallard, Alistair R | |
dc.contributor.author | McGuckin, Michael A | |
dc.contributor.author | Fassett, Robert G. | |
dc.contributor.author | Croci, Ilaria | |
dc.contributor.author | Ramos, Joyce S | |
dc.date.accessioned | 2019-09-30T07:15:40Z | |
dc.date.available | 2019-09-30T07:15:40Z | |
dc.date.created | 2019-07-18T18:10:51Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Nutrients. 2019, 11 (4), 1-10. | nb_NO |
dc.identifier.issn | 2072-6643 | |
dc.identifier.uri | http://hdl.handle.net/11250/2619266 | |
dc.description.abstract | The positive effects of dietary fibre on gut barrier function and inflammation have not been completely elucidated. Mice studies show gut barrier disruption and diet-induced insulin resistance can be alleviated by cytokine interleukin-22 (IL-22). However, little is known about IL-22 in humans and its association with gut-beneficial nutrients like fibre. We investigated whether fibre intake was associated with circulating levels of IL-22 in 48 participants with metabolic syndrome (MetS). Bivariate analysis was used to explore associations between circulating IL-22, fibre intake, MetS factors, body composition, and cardiorespiratory fitness (peak oxygen uptake, V˙ O2peak). Hierarchical multiple regression (HMR) was used to test the independent association of fibre intake with circulating IL-22, adjusting for variables correlated with IL-22. Circulating IL-22 was positively associated with fibre intake (rs = 0.393, p < 0.006). The HMR-adjusted model explained 40% of circulating IL-22 variability, and fibre intake significantly improved the prediction model by 8.4% (p < 0.022). Participants with fibre intake above median intake of 21.5 g/day had a significantly higher circulating IL-22 than the lower intake group (308.3 ± 454.4 vs. 69.0 ± 106.4 pg/mL, p < 0.019). Fibre intake is independently associated with increased circulating IL-22 in individuals with MetS. Findings warrant further investigations to evaluate whether changes in dietary fibre intake alter circulating IL-22, and its effects on health outcomes. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | MDPI | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Fibre Intake Is Independently Associated with Increased Circulating Interleukin-22 in Individuals with Metabolic Syndrome | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 1-10 | nb_NO |
dc.source.volume | 11 | nb_NO |
dc.source.journal | Nutrients | nb_NO |
dc.source.issue | 4 | nb_NO |
dc.identifier.doi | 10.3390/nu11040815 | |
dc.identifier.cristin | 1712007 | |
dc.description.localcode | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | nb_NO |
cristin.unitcode | 194,65,25,0 | |
cristin.unitname | Institutt for sirkulasjon og bildediagnostikk | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |