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dc.contributor.authorGrinde, Maria Tunset
dc.contributor.authorGiskeødegård, Guro F.
dc.contributor.authorAndreassen, Trygve
dc.contributor.authorTessem, May-Britt
dc.contributor.authorBathen, Tone Frost
dc.contributor.authorMoestue, Siver Andreas
dc.date.accessioned2019-09-19T11:21:18Z
dc.date.available2019-09-19T11:21:18Z
dc.date.created2019-01-04T14:02:45Z
dc.date.issued2019
dc.identifier.issn1064-3745
dc.identifier.urihttp://hdl.handle.net/11250/2617655
dc.description.abstractNMR-based metabolomics has shown promise in the diagnosis of diseases as it enables identification and quantification of metabolic biomarkers. Using high-resolution magic-angle-spinning (HR-MAS) NMR spectroscopy, metabolic profiles from intact tissue specimens can be obtained with high spectral resolution. In addition, HR-MAS NMR requires minimal sample preparation and the sample is kept intact for subsequent analyses. In this chapter, we describe a typical protocol for NMR-based metabolomics of tissue samples. We cover all major steps ranging from tissue sample collection to determination of biomarkers, including experimental precautions taken to ensure reproducible and reliable reporting of data in the area of clinical application.nb_NO
dc.language.isoengnb_NO
dc.publisherSpringer Verlagnb_NO
dc.titleBiomarker discovery using NMR based metabolomics of tissuenb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.journalMethods in molecular biologynb_NO
dc.identifier.doi10.1007/978-1-4939-9690-2_15
dc.identifier.cristin1650500
dc.relation.projectNorges forskningsråd: 239940nb_NO
dc.description.localcodeThis is a post-peer-review, pre-copyedit version of an article published in [Methods in molecular biology] Locked until 29.8.2020 due to copyright restrictions. The final authenticated version is available online at: https://doi.org/10.1007/978-1-4939-9690-2_15nb_NO
cristin.unitcode194,65,25,0
cristin.unitcode194,65,15,0
cristin.unitnameInstitutt for sirkulasjon og bildediagnostikk
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.ispublishedfalse
cristin.fulltextpostprint
cristin.qualitycode1


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