dc.contributor.author | Grinde, Maria Tunset | |
dc.contributor.author | Giskeødegård, Guro F. | |
dc.contributor.author | Andreassen, Trygve | |
dc.contributor.author | Tessem, May-Britt | |
dc.contributor.author | Bathen, Tone Frost | |
dc.contributor.author | Moestue, Siver Andreas | |
dc.date.accessioned | 2019-09-19T11:21:18Z | |
dc.date.available | 2019-09-19T11:21:18Z | |
dc.date.created | 2019-01-04T14:02:45Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1064-3745 | |
dc.identifier.uri | http://hdl.handle.net/11250/2617655 | |
dc.description.abstract | NMR-based metabolomics has shown promise in the diagnosis of diseases as it enables identification and quantification of metabolic biomarkers. Using high-resolution magic-angle-spinning (HR-MAS) NMR spectroscopy, metabolic profiles from intact tissue specimens can be obtained with high spectral resolution. In addition, HR-MAS NMR requires minimal sample preparation and the sample is kept intact for subsequent analyses. In this chapter, we describe a typical protocol for NMR-based metabolomics of tissue samples. We cover all major steps ranging from tissue sample collection to determination of biomarkers, including experimental precautions taken to ensure reproducible and reliable reporting of data in the area of clinical application. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Springer Verlag | nb_NO |
dc.title | Biomarker discovery using NMR based metabolomics of tissue | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | acceptedVersion | nb_NO |
dc.source.journal | Methods in molecular biology | nb_NO |
dc.identifier.doi | 10.1007/978-1-4939-9690-2_15 | |
dc.identifier.cristin | 1650500 | |
dc.relation.project | Norges forskningsråd: 239940 | nb_NO |
dc.description.localcode | This is a post-peer-review, pre-copyedit version of an article published in [Methods in molecular biology] Locked until 29.8.2020 due to copyright restrictions. The final authenticated version is available online at: https://doi.org/10.1007/978-1-4939-9690-2_15 | nb_NO |
cristin.unitcode | 194,65,25,0 | |
cristin.unitcode | 194,65,15,0 | |
cristin.unitname | Institutt for sirkulasjon og bildediagnostikk | |
cristin.unitname | Institutt for klinisk og molekylær medisin | |
cristin.ispublished | false | |
cristin.fulltext | postprint | |
cristin.qualitycode | 1 | |