dc.contributor.author | Souza, Rodrigo W. A. | |
dc.contributor.author | Alves, Christiano R. R. | |
dc.contributor.author | Medeiros, Alessandra | |
dc.contributor.author | Rolim, Natale Pinheiro Lage | |
dc.contributor.author | Silva, Gustavo Jose Justo | |
dc.contributor.author | Moreira, Jose Bianco Nascimento | |
dc.contributor.author | Alves, Marcia Netto Magalhaes | |
dc.contributor.author | Wohlwend, Martin | |
dc.contributor.author | Gebriel, Mohammed | |
dc.contributor.author | Hagen, Lars | |
dc.contributor.author | Sharma, Animesh | |
dc.contributor.author | Koch, Lauren G. | |
dc.contributor.author | Britton, Steven L. | |
dc.contributor.author | Slupphaug, Geir | |
dc.contributor.author | Wisløff, Ulrik | |
dc.contributor.author | Brum, Patricia C. | |
dc.date.accessioned | 2019-09-13T06:57:02Z | |
dc.date.available | 2019-09-13T06:57:02Z | |
dc.date.created | 2019-01-03T15:34:52Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Scientific Reports. 2018, 8 (1), . | nb_NO |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/11250/2616677 | |
dc.description.abstract | Given the association between high aerobic capacity and the prevention of metabolic diseases, elucidating the mechanisms by which high aerobic capacity regulates whole-body metabolic homeostasis is a major research challenge. Oxidative post-translational modifications (Ox-PTMs) of proteins can regulate cellular homeostasis in skeletal and cardiac muscles, but the relationship between Ox-PTMs and intrinsic components of oxidative energy metabolism is still unclear. Here, we evaluated the Ox-PTM profile in cardiac and skeletal muscles of rats bred for low (LCR) and high (HCR) intrinsic aerobic capacity. Redox proteomics screening revealed different cysteine (Cys) Ox-PTM profile between HCR and LCR rats. HCR showed a higher number of oxidized Cys residues in skeletal muscle compared to LCR, while the opposite was observed in the heart. Most proteins with differentially oxidized Cys residues in the skeletal muscle are important regulators of oxidative metabolism. The most oxidized protein in the skeletal muscle of HCR rats was malate dehydrogenase (MDH1). HCR showed higher MDH1 activity compared to LCR in skeletal, but not cardiac muscle. These novel findings indicate a clear association between Cys Ox-PTMs and aerobic capacity, leading to novel insights into the role of Ox-PTMs as an essential signal to maintain metabolic homeostasis. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Nature Research | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 13 | nb_NO |
dc.source.volume | 8 | nb_NO |
dc.source.journal | Scientific Reports | nb_NO |
dc.source.issue | 1 | nb_NO |
dc.identifier.doi | 10.1038/s41598-018-35728-2 | |
dc.identifier.cristin | 1649853 | |
dc.relation.project | Notur/NorStore: NS9036K | nb_NO |
dc.description.localcode | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | nb_NO |
cristin.unitcode | 194,65,25,0 | |
cristin.unitcode | 194,65,15,0 | |
cristin.unitname | Institutt for sirkulasjon og bildediagnostikk | |
cristin.unitname | Institutt for klinisk og molekylær medisin | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |