dc.contributor.author | Muller, David C. | |
dc.contributor.author | Hodge, Allison M. | |
dc.contributor.author | Fanidi, Anouar | |
dc.contributor.author | Albanes, Demetrius | |
dc.contributor.author | Mai, Xiao-Mei | |
dc.contributor.author | Shu, Xiao Ou | |
dc.contributor.author | Weinstein, Stephanie J. | |
dc.contributor.author | Larose, Tricia L | |
dc.contributor.author | Zhang, Xuehong | |
dc.contributor.author | Han, Jingquan | |
dc.contributor.author | Stampfer, Meir J. | |
dc.contributor.author | Smith-Warner, Stephanie A. | |
dc.contributor.author | Ma, Jing | |
dc.contributor.author | Gaziano, John Michael | |
dc.contributor.author | Sesso, Howard D. | |
dc.contributor.author | Stevens, Victoria L. | |
dc.contributor.author | McCullough, Marjorie L. | |
dc.contributor.author | Layne, Tracy M. | |
dc.contributor.author | Prentice, Ross | |
dc.contributor.author | Pettinger, Mary | |
dc.contributor.author | Thomson, Cynthia A. | |
dc.contributor.author | Zheng, Wei | |
dc.contributor.author | Gao, Yutang | |
dc.contributor.author | Rothman, Nathaniel | |
dc.contributor.author | Xiang, Yong-Bing | |
dc.contributor.author | Cai, Hui | |
dc.contributor.author | Wang, Rui | |
dc.contributor.author | Yuan, Jian-Min | |
dc.contributor.author | Koh, Woon-Puay | |
dc.contributor.author | Butler, Lesley M. | |
dc.contributor.author | Cai, Qiuyin | |
dc.contributor.author | Blot, William James | |
dc.contributor.author | Wu, Jie | |
dc.contributor.author | Ueland, Per Magne | |
dc.contributor.author | Midttun, Øivind | |
dc.contributor.author | Langhammer, Arnulf | |
dc.contributor.author | Hveem, Kristian | |
dc.contributor.author | Johansson, Mikael B. | |
dc.contributor.author | Hultdin, Johan | |
dc.contributor.author | Grankvist, Kjell | |
dc.contributor.author | Arslan, Alan A. | |
dc.contributor.author | Le Marchand, Loïc | |
dc.contributor.author | Severi, Gianluca | |
dc.contributor.author | Johansson, Mattias | |
dc.contributor.author | Brennan, Paul | |
dc.date.accessioned | 2019-09-09T06:04:00Z | |
dc.date.available | 2019-09-09T06:04:00Z | |
dc.date.created | 2018-03-16T15:04:24Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Annals of Oncology. 2018, 29 (6), 1468-1475. | nb_NO |
dc.identifier.issn | 0923-7534 | |
dc.identifier.uri | http://hdl.handle.net/11250/2613835 | |
dc.description.abstract | Background
There is observational evidence suggesting that high vitamin D concentrations may protect against lung cancer. To investigate this hypothesis in detail, we measured circulating vitamin D concentrations in prediagnostic blood from 20 cohorts participating in the Lung Cancer Cohort Consortium (LC3).
Patients and methods
The study included 5313 lung cancer cases and 5313 controls. Blood samples for the cases were collected, on average, 5 years before lung cancer diagnosis. Controls were individually matched to the cases by cohort, sex, age, race/ethnicity, date of blood collection, and smoking status in five categories. Liquid chromatography coupled with tandem mass spectrometry was used to separately analyze 25-hydroxyvitamin D2 [25(OH)D2] and 25-hydroxyvitamin D3 [25(OH)D3] and their concentrations were combined to give an overall measure of 25(OH)D. We used conditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for 25(OH)D as both continuous and categorical variables.
Results
Overall, no apparent association between 25(OH)D and risk of lung cancer was observed (multivariable adjusted OR for a doubling in concentration: 0.98, 95% CI: 0.91, 1.06). Similarly, we found no clear evidence of interaction by cohort, sex, age, smoking status, or histology.
Conclusion
This study did not support an association between vitamin D concentrations and lung cancer risk. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Oxford University Press | nb_NO |
dc.title | No association between circulating concentrations of vitamin D and risk of lung cancer: An analysis in 20 prospective studies in the Lung Cancer Cohort Consortium (LC3) | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 1468-1475 | nb_NO |
dc.source.volume | 29 | nb_NO |
dc.source.journal | Annals of Oncology | nb_NO |
dc.source.issue | 6 | nb_NO |
dc.identifier.doi | 10.1093/annonc/mdy104 | |
dc.identifier.cristin | 1573558 | |
dc.relation.project | Norges forskningsråd: 267776/H10 | nb_NO |
dc.description.localcode | VC The Author(s) 2018. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com. | nb_NO |
cristin.unitcode | 194,65,20,0 | |
cristin.unitcode | 194,65,20,15 | |
cristin.unitname | Institutt for samfunnsmedisin og sykepleie | |
cristin.unitname | Helseundersøkelsen i Nord-Trøndelag | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |