Show simple item record

dc.contributor.authorMuller, David C.
dc.contributor.authorHodge, Allison M.
dc.contributor.authorFanidi, Anouar
dc.contributor.authorAlbanes, Demetrius
dc.contributor.authorMai, Xiao-Mei
dc.contributor.authorShu, Xiao Ou
dc.contributor.authorWeinstein, Stephanie J.
dc.contributor.authorLarose, Tricia L
dc.contributor.authorZhang, Xuehong
dc.contributor.authorHan, Jingquan
dc.contributor.authorStampfer, Meir J.
dc.contributor.authorSmith-Warner, Stephanie A.
dc.contributor.authorMa, Jing
dc.contributor.authorGaziano, John Michael
dc.contributor.authorSesso, Howard D.
dc.contributor.authorStevens, Victoria L.
dc.contributor.authorMcCullough, Marjorie L.
dc.contributor.authorLayne, Tracy M.
dc.contributor.authorPrentice, Ross
dc.contributor.authorPettinger, Mary
dc.contributor.authorThomson, Cynthia A.
dc.contributor.authorZheng, Wei
dc.contributor.authorGao, Yutang
dc.contributor.authorRothman, Nathaniel
dc.contributor.authorXiang, Yong-Bing
dc.contributor.authorCai, Hui
dc.contributor.authorWang, Rui
dc.contributor.authorYuan, Jian-Min
dc.contributor.authorKoh, Woon-Puay
dc.contributor.authorButler, Lesley M.
dc.contributor.authorCai, Qiuyin
dc.contributor.authorBlot, William James
dc.contributor.authorWu, Jie
dc.contributor.authorUeland, Per Magne
dc.contributor.authorMidttun, Øivind
dc.contributor.authorLanghammer, Arnulf
dc.contributor.authorHveem, Kristian
dc.contributor.authorJohansson, Mikael B.
dc.contributor.authorHultdin, Johan
dc.contributor.authorGrankvist, Kjell
dc.contributor.authorArslan, Alan A.
dc.contributor.authorLe Marchand, Loïc
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorJohansson, Mattias
dc.contributor.authorBrennan, Paul
dc.date.accessioned2019-09-09T06:04:00Z
dc.date.available2019-09-09T06:04:00Z
dc.date.created2018-03-16T15:04:24Z
dc.date.issued2018
dc.identifier.citationAnnals of Oncology. 2018, 29 (6), 1468-1475.nb_NO
dc.identifier.issn0923-7534
dc.identifier.urihttp://hdl.handle.net/11250/2613835
dc.description.abstractBackground There is observational evidence suggesting that high vitamin D concentrations may protect against lung cancer. To investigate this hypothesis in detail, we measured circulating vitamin D concentrations in prediagnostic blood from 20 cohorts participating in the Lung Cancer Cohort Consortium (LC3). Patients and methods The study included 5313 lung cancer cases and 5313 controls. Blood samples for the cases were collected, on average, 5 years before lung cancer diagnosis. Controls were individually matched to the cases by cohort, sex, age, race/ethnicity, date of blood collection, and smoking status in five categories. Liquid chromatography coupled with tandem mass spectrometry was used to separately analyze 25-hydroxyvitamin D2 [25(OH)D2] and 25-hydroxyvitamin D3 [25(OH)D3] and their concentrations were combined to give an overall measure of 25(OH)D. We used conditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for 25(OH)D as both continuous and categorical variables. Results Overall, no apparent association between 25(OH)D and risk of lung cancer was observed (multivariable adjusted OR for a doubling in concentration: 0.98, 95% CI: 0.91, 1.06). Similarly, we found no clear evidence of interaction by cohort, sex, age, smoking status, or histology. Conclusion This study did not support an association between vitamin D concentrations and lung cancer risk.nb_NO
dc.language.isoengnb_NO
dc.publisherOxford University Pressnb_NO
dc.titleNo association between circulating concentrations of vitamin D and risk of lung cancer: An analysis in 20 prospective studies in the Lung Cancer Cohort Consortium (LC3)nb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber1468-1475nb_NO
dc.source.volume29nb_NO
dc.source.journalAnnals of Oncologynb_NO
dc.source.issue6nb_NO
dc.identifier.doi10.1093/annonc/mdy104
dc.identifier.cristin1573558
dc.relation.projectNorges forskningsråd: 267776/H10nb_NO
dc.description.localcodeVC The Author(s) 2018. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.nb_NO
cristin.unitcode194,65,20,0
cristin.unitcode194,65,20,15
cristin.unitnameInstitutt for samfunnsmedisin og sykepleie
cristin.unitnameHelseundersøkelsen i Nord-Trøndelag
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record