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dc.contributor.authorDiaz Verdugo, Carmen
dc.contributor.authorMyren-Svelstad, Sverre
dc.contributor.authorAydin, Ecem
dc.contributor.authorVan Hoeymissen, Evelien
dc.contributor.authorDeneubourg, Celine
dc.contributor.authorVanderhaeghe, Silke
dc.contributor.authorVancraeynest, Julie
dc.contributor.authorPelgrims, Robbrecht
dc.contributor.authorCasacak, Mehmet Ilyas
dc.contributor.authorMuto, Akira
dc.contributor.authorKawakami, Koichi
dc.contributor.authorJurisch-Yaksi, Nathalie
dc.contributor.authorYaksi, Emre
dc.date.accessioned2019-08-30T06:42:43Z
dc.date.available2019-08-30T06:42:43Z
dc.date.created2019-08-29T13:17:34Z
dc.date.issued2019
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11250/2611696
dc.description.abstractBrain activity and connectivity alter drastically during epileptic seizures. The brain networks shift from a balanced resting state to a hyperactive and hypersynchronous state. It is, however, less clear which mechanisms underlie the state transitions. By studying neural and glial activity in zebrafish models of epileptic seizures, we observe striking differences between these networks. During the preictal period, neurons display a small increase in synchronous activity only locally, while the gap-junction-coupled glial network was highly active and strongly synchronized across large distances. The transition from a preictal state to a generalized seizure leads to an abrupt increase in neural activity and connectivity, which is accompanied by a strong alteration in glia-neuron interactions and a massive increase in extracellular glutamate. Optogenetic activation of glia excites nearby neurons through the action of glutamate and gap junctions, emphasizing a potential role for glia-glia and glia-neuron connections in the generation of epileptic seizures.nb_NO
dc.language.isoengnb_NO
dc.publisherNature Researchnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleGlia-neuron interactions underlie state transitions to generalized seizuresnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.volume10nb_NO
dc.source.journalNature Communicationsnb_NO
dc.identifier.doi10.1038/s41467-019-11739-z
dc.identifier.cristin1719864
dc.description.localcode© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)nb_NO
cristin.unitcode194,65,60,0
cristin.unitcode194,65,30,0
cristin.unitnameKavliinstitutt for nevrovitenskap
cristin.unitnameInstitutt for nevromedisin og bevegelsesvitenskap
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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