Blar i St. Olavs hospital på tidsskrift "Journal of Controlled Release"

Viser treff 1-3 av 3

    • Effect of acoustic cluster therapy (ACT®) combined with chemotherapy in a patient-derived xenograft mouse model of pancreatic cancer 

      Ng, Serina; Healey, Andrew J.; Sontum, Per Christian; Kvåle, Svein; Torp, Sverre Helge; Sulheim, Einar; Von Hoff, Daniel; Han, Haiyoung (Peer reviewed; Journal article, 2022)
      Pancreatic ductal adenocarcinomas respond poorly to chemotherapy, in part due to the dense tumor stroma that hinders drug delivery. Ultrasound (US) in combination with microbubbles has previously shown promise as a means ...

    • Multi-modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models 

      Sulheim, Einar; Kim, Jana; van Wamel, Annemieke; Kim, Eugene; Snipstad, Sofie; Vidic, Igor; Grimstad, Ingeborg; Widerøe, Marius; Torp, Sverre Helge; Lundgren, Steinar; Waxman, David J.; Davies, Catharina de Lange (Journal article; Peer reviewed, 2018)
      Preclinical research has demonstrated that nanoparticles and macromolecules can accumulate in solid tumors due to the enhanced permeability and retention effect. However, drug loaded nanoparticles often fail to show increased ...

    • Ultrasound-mediated delivery enhances therapeutic efficacy of MMP sensitive liposomes 

      Olsman, Marieke; Sereti, Viktoria; Andreassen, Kristine; Snipstad, Linn Sofie; van Wamel, Johanna Elisabeth Theodora; Eliasen, Rasmus; Berg, Sigrid; Urquhart, Andrew J.; Andresen, Thomas L.; Davies, Ruth Catharina de Lange (Peer reviewed; Journal article, 2020)
      To improve therapeutic efficacy of nanocarrier drug delivery systems, it is essential to improve their uptake and penetration in tumour tissue, enhance cellular uptake and ensure efficient drug release at the tumour site. ...