Blar i St. Olavs hospital på tidsskrift "Human Molecular Genetics"
Viser treff 1-6 av 6
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Detailed stratified GWAS analysis for severe COVID-19 in four European populations
(Peer reviewed; Journal article, 2022)Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease ... -
Genome-wide association study of cardiac troponin i in the general population
(Peer reviewed; Journal article, 2021)Circulating cardiac troponin proteins are associated with structural heart disease and predict incident cardiovascular disease in the general population. However, the genetic contribution to cardiac troponin I (cTnI) ... -
A novel somatic mutation in GNB2 provides new insights to the pathogenesis of Sturge-Weber syndrome
(Peer reviewed; Journal article, 2021)Sturge–Weber syndrome (SWS) is a neurocutaneous disorder characterized by vascular malformations affecting skin, eyes and leptomeninges of the brain, which can lead to glaucoma, seizures and intellectual disability. The ... -
Separating the genetics of childhood and adult obesity: a validation study of genetic scores for body mass index in adolescence and adulthood in the HUNT Study
(Peer reviewed; Journal article, 2020)From a life-course perspective, genetic and environmental factors driving childhood obesity may have a lasting inf luence on health later in life. However, how obesity trajectories vary throughout the life-course remains ... -
Thyroid function, pernicious anemia and erythropoiesis: a two-sample Mendelian randomization study
(Peer reviewed; Journal article, 2022)Autoimmune thyroid disease (AITD) and pernicious anemia (PA) often coexist, but the directionality is unknown. In a two-sample Mendelian randomization (MR) analysis, using summary statistics from large genome-wide association ... -
Within family Mendelian randomization studies
(Peer reviewed; Journal article, 2019)Mendelian randomization (MR) is increasingly used to make causal inferences in a wide range of fields, from drug development to etiologic studies. Causal inference in MR is possible because of the process of genetic ...